Results 11 to 20 of about 59,802 (286)
Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm [PDF]
Molecular Reproduction and Development, 2008 Hexokinase is the first enzyme in the glycolytic pathway and utilizes ATP to convert glucose to glucose-6-phosphate (G6P). We previously identified three variant transcripts of Hk1 that are expressed specifically in spermatogenic cells, have different 5′
O'Brien, Deborah A. +4 more
core +4 more sources
Hexokinases and cardioprotection [PDF]
Journal of Molecular and Cellular Cardiology, 2015 As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione reduction, and modulate cell death processes by directly interacting with the voltage-dependent anion channel (VDAC), a regulatory component of ...
Calmettes, Guillaume +5 more
openaire +4 more sources
Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non-Metabolic Function of Hexokinase 2. [PDF]
Cell ProlifHK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Lin Z +9 more
europepmc +2 more sources
Molecules, 2021 Two series of novel amino acid Schiff base ligands containing heterocyclic moieties, such as quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by spectroscopic techniques and elemental analysis.
Ahmed A. Noser +3 more
doaj +1 more source
Frontiers in Plant Science, 2018 Hexokinases is a family of proteins that is found in all eukaryotes. Hexokinases play key roles in the primary carbon metabolism, where they catalyze the phosphorylation of glucose and fructose, but they have also been shown to be involved in glucose ...
Mikael Ulfstedt +3 more
doaj +1 more source
Frontiers in Immunology, 2022 White spot syndrome virus (WSSV) is the causative agent of a shrimp disease that inflicts in huge economic losses in shrimp-farming industry. WSSV triggers aerobic glycolysis in shrimp immune cells (hemocytes), but how this virus regulates glycolytic ...
Yen Siong Ng +6 more
doaj +1 more source
Phosphorylation of yeast hexokinases [PDF]
European Journal of Biochemistry, 1990 We show by the use of 32P‐labeling in vivo that hexokinase 2 and hexokinase 1 in Saccharomyces cerevisiae are phosphoproteins. The highest labeling was after incubation in medium with a low concentration of glucose, when labeling appears to be predominant even without use of immunoprecipitation.
A B, Vojtek, D G, Fraenkel
openaire +2 more sources
Open Life Sciences, 2023 Hexokinase 2 (HK2) has been associated with carcinogenic growth in numerous kinds of malignancies as essential regulators during the processing of glucose.
Zhao Hongcan +4 more
doaj +1 more source
Pharmaceutical Biology, 2017 Context: Geraniol, an acyclic monoterpene alcohol is found in medicinal plants, is used traditionally for several medical purposes including diabetes. Objectives: The present study evaluates the antihyperglycemic potential of geraniol on key enzymes of ...
Sukumar Babukumar +3 more
doaj +1 more source
Guard-Cell Hexokinase Increases Water-Use Efficiency Under Normal and Drought Conditions
Frontiers in Plant Science, 2019 Water is a limiting resource for many land plants. Most of the water taken up by plants is lost to the atmosphere through the stomata, which are adjustable pores on the leaf surface that allow for gas exchange between the plant and the atmosphere ...
Gilor Kelly +6 more
doaj +1 more source