Results 11 to 20 of about 58,740 (306)

Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes [PDF]

, 2022
The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin resistance and vascular ...
Rabbani, Naila, Naila Rabbani (291722), Paul J. Thornalley (291723), Paul J. Thornalley, Mingzhan Xue, Naila Rabbani, Xue, Mingzhan, Thornalley, Paul J., Mingzhan Xue (3607649)   +8 more
core   +1 more source

Indications for a Central Role of Hexokinase Activity in Natural Variation of Heat Acclimation in Arabidopsis thaliana

Plants, 2020
Diurnal and seasonal changes of abiotic environmental factors shape plant performance and distribution. Changes of growth temperature and light intensity may vary significantly on a diurnal, but also on a weekly or seasonal scale. Hence, acclimation to a
Vasil Atanasov, Lisa Fürtauer, Thomas Nägele   +2 more
doaj   +1 more source

New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway

Molecules, 2021
Two series of novel amino acid Schiff base ligands containing heterocyclic moieties, such as quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by spectroscopic techniques and elemental analysis.
Ahmed A. Noser, Aboubakr H. Abdelmonsef, Mohamed El-Naggar, Maha M. Salem   +3 more
doaj   +1 more source

Molecular bases of hexokinase deficiency [PDF]

, 1997
Hexokinase (ATP: d-hexose 6-phosphotransferase, EC 2.7.1.1; HK) deficiency is a rare disease where the predominant clinical effect is nonspherocytic hemolytic anemia. We have previously shown that the only patient for which hexokinase deficiency has been
SERAFINI, GIORDANO, CRINELLI, RITA, MAGNANI, MAURO, GIAMMARINI C, BIANCHI, MARZIA, Giammarini, Camilla   +5 more
core   +1 more source

The Ability of a Charophyte Alga Hexokinase to Restore Glucose Signaling and Glucose Repression of Gene Expression in a Glucose-Insensitive Arabidopsis Hexokinase Mutant Depends on Its Catalytic Activity

Frontiers in Plant Science, 2018
Hexokinases is a family of proteins that is found in all eukaryotes. Hexokinases play key roles in the primary carbon metabolism, where they catalyze the phosphorylation of glucose and fructose, but they have also been shown to be involved in glucose ...
Mikael Ulfstedt, Guo-Zhen Hu, D. Magnus Eklund, Hans Ronne   +3 more
doaj   +1 more source

White Spot Syndrome Virus Triggers a Glycolytic Pathway in Shrimp Immune Cells (Hemocytes) to Benefit Its Replication

Frontiers in Immunology, 2022
White spot syndrome virus (WSSV) is the causative agent of a shrimp disease that inflicts in huge economic losses in shrimp-farming industry. WSSV triggers aerobic glycolysis in shrimp immune cells (hemocytes), but how this virus regulates glycolytic ...
Yen Siong Ng, Der-Yen Lee, Chun-Hung Liu, Cheng-Yi Tung, Shu-Ting He, Han-Ching Wang, Han-Ching Wang   +6 more
doaj   +1 more source

Phosphorylation of yeast hexokinases [PDF]

European Journal of Biochemistry, 1990
We show by the use of 32P‐labeling in vivo that hexokinase 2 and hexokinase 1 in Saccharomyces cerevisiae are phosphoproteins. The highest labeling was after incubation in medium with a low concentration of glucose, when labeling appears to be predominant even without use of immunoprecipitation.
A B, Vojtek, D G, Fraenkel
openaire   +2 more sources

HK2 contributes to the proliferation, migration, and invasion of diffuse large B-cell lymphoma cells by enhancing the ERK1/2 signaling pathway

Open Life Sciences, 2023
Hexokinase 2 (HK2) has been associated with carcinogenic growth in numerous kinds of malignancies as essential regulators during the processing of glucose.
Zhao Hongcan, Xiang Guoqian, Shao Tingjun, Wang Minmin, Dai Weijian   +4 more
doaj   +1 more source

Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

Pharmaceutical Biology, 2017
Context: Geraniol, an acyclic monoterpene alcohol is found in medicinal plants, is used traditionally for several medical purposes including diabetes. Objectives: The present study evaluates the antihyperglycemic potential of geraniol on key enzymes of ...
Sukumar Babukumar, Veerasamy Vinothkumar, Chandrasekaran Sankaranarayanan, Subramani Srinivasan   +3 more
doaj   +1 more source

Guard-Cell Hexokinase Increases Water-Use Efficiency Under Normal and Drought Conditions

Frontiers in Plant Science, 2019
Water is a limiting resource for many land plants. Most of the water taken up by plants is lost to the atmosphere through the stomata, which are adjustable pores on the leaf surface that allow for gas exchange between the plant and the atmosphere ...
Gilor Kelly, Aiman Egbaria, Belal Khamaisi, Nitsan Lugassi, Ziv Attia, Menachem Moshelion, David Granot   +6 more
doaj   +1 more source