Results 61 to 70 of about 17,223 (183)

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3868-3881, November 2026.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the livers⃞

Journal of Lipid Research, 2007
Glucose disposal induces a signal that modulates the transcriptional regulation of genes involved in the glycolysis and lipogenesis pathways. To investigate the role of glucose metabolism on hepatic gene expression independently from insulin action, we ...
Núria Morral, Howard J. Edenberg, Scott R. Witting, Jennifer Altomonte, Tearina Chu, Matthew Brown   +5 more
doaj   +1 more source

Circadian rhythm, glucose metabolism and diabetic complications: the role of glucokinase and the enlightenment on future treatment

Frontiers in Physiology
The circadian clock, an innate timing mechanism, governs a variety of physiological activities by producing near-24-h cycles in gene expression. These cycles are reflected in patterns of metabolism and behavior.
Zhijun Zhang, Shuo Wang, Ling Gao
doaj   +1 more source

Clinical investigation of glucokinase activators for the restoration of glucose homeostasis in diabetes

Journal of Diabetes
As a sensor, glucokinase (GK) controls glucose homeostasis, which progressively declines in patients with diabetes. GK maintains the equilibrium of glucose levels and regulates the homeostatic system set points.
Ping Li, Dalong Zhu
doaj   +1 more source

Ontogenic Profile of Hexokinase and Glucokinase mRNA Expressions in Embryonic Chicken Liver and Muscle

The Journal of Poultry Science, 2013
The present study describes ontogenic profile of mRNA expressions of hexokinase (HK; EC 2.7.1.1) and glucokinase (GK; EC 2.7.1.2, otherwise known as HKIV) that catalyze the first step of glucose metabolism by cells.
Tushar K. Roy, Atsushi Iwasawa, Yasutake Shimizu, Koji Kageyama, Norio Yoshizaki   +4 more
doaj   +1 more source

A synonymous variant in GCK gene as a cause of gestational diabetes mellitus

Сахарный диабет, 2019
The diagnosis of MODY as a subtype of gestational diabetes mellitus (GDM) is important for an adequate management during pregnancy and the postnatal period.
Natalia A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasilyev, Vasily M. Petrov, Anatoly N. Tiulpakov   +7 more
doaj   +1 more source

Molecular Physiology of Mammalian Glucokinase [PDF]

Cellular and Molecular Life Sciences, 2008
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human "diabetes gene". Subsequently, important advances were made in understanding the impact of GCK in the regulation of glucose metabolism. Structure elucidation by crystallography provided insight into the kinetic properties of GCK.
openaire   +4 more sources

Sugar‐sensing swodkoreceptors and swodkocrine signaling

Animal Models and Experimental Medicine
Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules.
Savani Anbalagan
doaj   +1 more source

Sapium ellipticum (Hochst) Pax ethanol leaf extract modulates glucokinase and glucose-6-phosphatase activities in streptozotocin induced diabetic rats

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To examine the effects of Sapium ellipticum (SE) leaf extract on the hepatic activities of glucokinase and glucose-6-phosphatase in streptozotocin-induced diabetic Wistar rats.
Osasenaga Macdonald Ighodaro, Oluseyi Adeboye Akinloye, Regina Ngozi Ugbaja, Samuel Olatunbosun Omotainse   +3 more
doaj   +1 more source

New Solutions in Single-Cell Protein Production from Methane: Construction of Glycogen-Deficient Mutants of Methylococcus capsulatus MIR

Fermentation
The biotechnology of converting methane to single-cell protein (SCP) implies using fast-growing thermotolerant aerobic methanotrophic bacteria. Among the latter, members of the genus Methylococcus received significant research attention and are used in ...
Sergey Y. But, Ruslan Z. Suleimanov, Igor Y. Oshkin, Olga N. Rozova, Ildar I. Mustakhimov, Nikolai V. Pimenov, Svetlana N. Dedysh, Valentina N. Khmelenina   +7 more
doaj   +1 more source