Results 31 to 40 of about 31,450 (226)

Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of Entada africana toward Glucokinase Stimulation: Computational Insight

Molecules, 2023
Glucokinase plays an important role in regulating the blood glucose level and serves as an essential therapeutic target in type 2 diabetes management. Entada africana is a medicinal plant and highly rich source of bioactive ligands with the potency to ...
Sunday Amos Onikanni, Bashir Lawal, Valens Munyembaraga, Oluwafemi Shittu Bakare, Muhammad Taher, Junaidi Khotib, Deny Susanti, Babatunji Emmanuel Oyinloye, Lloyd Noriega, Ayodeji Famuti, Adewale Oluwaseun Fadaka, Basiru Olaitan Ajiboye   +11 more
doaj   +1 more source

Specific insulin and proinsulin secretion in glucokinase-deficient individuals

Brazilian Journal of Medical and Biological Research, 1999
Glucokinase (GCK) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. Mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young (MODY).
V.C. Pardini, G. Velho, R. Reis, S. Purisch, H. Blanché, J.G.H. Vieira, R.C.S. Moisés   +6 more
doaj   +1 more source

Sirtuin functions and modulation: from chemistry to the clinic [PDF]

, 2016
Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell ...
Altucci, Lucia, Carafa, Vincenzo, Cuomo, Francesca, Forgione, Mariantonietta, Hailu, GEBREMEDHIN SOLOMON, Jarho, Elina, Lahtela Kakkonen, Maija, Mai, Antonello, Rotili, Dante, Serretiello, Enrica   +9 more
core   +2 more sources

Evaluation of polygenic determinants of non-alcoholic fatty liver disease (NAFLD) by a candidate genes resequencing strategy [PDF]

, 2018
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 genes ...
Angelico F, Angeloni A, Arca M, Bailetti D, Baratta F, Belardinilli F, Ceci F, D'Erasmo L, De Masi B, Del Ben M, Di Costanzo A, Giannini G, Girelli G, Montali A, Pastori D, Polimeni L, Sponziello M   +16 more
core   +1 more source

GENETICS OF YEAST GLUCOKINASE [PDF]

Genetics, 1983
ABSTRACT Mutants of Saccharomyces cerevisiae lacking glucokinase (EC 2.7.1.2) have no discernible phenotypic difference from the wild-type strain; in a hexokinaseless background, however, they are unable to grow on any sugar except galactose. Reversion studies with glucokinase mutants indicate that the yeast S.
P K, Maitra, Z, Lobo
openaire   +2 more sources

Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene

Сахарный диабет, 2018
Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent form of monogenic diabetes mellitus (DM) presenting during pregnancy.
Natalia A. Zubkova, Fatima F. Burumkulova, Victoria I. Ulyatovskaya, Vasily A. Petrukhin, Margarita A. Plechanova, Anton E. Panov, Tatiana S. Budykina, Nina A. Makretskaya, Anatoly N. Tiulpakov   +8 more
doaj   +1 more source

Glucokinase and glucokinase regulatory protein: mutual dependence for nuclear localization [PDF]

Biochemical Journal, 2000
Conditional expression of the glucokinase regulatory protein in insulinoma cells, under control of the reverse tetracycline-dependent transactivator, was used to investigate whether expression of this protein de novo would alter the intracellular distribution of glucokinase.
D, Bosco, P, Meda, P B, Iynedjian
openaire   +2 more sources

EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS

Berkala Kedokteran, 2017
: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats.
Iskandar Thalib, Windy Yuliana Budianto, Eko Suhartono   +2 more
doaj   +1 more source

Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores [PDF]

, 2013
Carnivores, such as the dolphin and the domestic cat, have numerous adaptations that befit consumption of diets with high protein and fat content, with little carbohydrate content.
Schermerhorn, Thomas
core   +2 more sources

Glucokinase: evolution, regulatory properties, role in the pathogenesis of type 2 diabetes mellitus

Acta Biomedica Scientifica
The review examines the evolution, structural and functional organization and regulatory properties of glucokinase, which is predominantly expressed in β-cells of the pancreas and in liver hepatocytes.
L. A. Kuznetsova, N. E. Basova, A. O. Shpakov   +2 more
doaj   +1 more source