Results 31 to 40 of about 21,204 (221)

EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS

Berkala Kedokteran, 2017
: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats.
Iskandar Thalib, Windy Yuliana Budianto, Eko Suhartono   +2 more
doaj   +1 more source

Glucokinase: evolution, regulatory properties, role in the pathogenesis of type 2 diabetes mellitus

Acta Biomedica Scientifica
The review examines the evolution, structural and functional organization and regulatory properties of glucokinase, which is predominantly expressed in β-cells of the pancreas and in liver hepatocytes.
L. A. Kuznetsova, N. E. Basova, A. O. Shpakov   +2 more
doaj   +1 more source

Clinical, Laboratory and Genetic Characteristics of Children with GCK-MODY (MODY2): Report of Four Novel Variants in GCK Gene

Trends in Pediatrics, 2020
Objective: Maturity-Onset Diabetes of the Young (MODY) is the most common type of monogenic diabetes. Heterozygous inactivating variants in glucokinase (GCK) gene are related to MODY2 (GCK–MODY).
Mustafa Altan, Ayşe Anık, Nilay Tuğçe Işık Bayar, Gokay Bozkurt, Tolga Ünüvar, Ahmet Anık   +5 more
doaj   +1 more source

The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase

Metabolites, 2021
Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber, Nicholas B. Whitticar, Daniel R. Rochester, Kathryn L. Corbin, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source

Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain

, 2001
Our previous description of functional glucokinase isoforms in the rat brain has opened new questions concerning the presence of glucokinase regulatory protein in the brain and the functional role of its interactions with glucokinase.
Blázquez Fernández, Enrique, Vázquez Pérez, Patricia, Chowen, Julie A., Álvarez García, Elvira, Roncero Rincón, Isabel   +4 more
core   +1 more source

Functional Glucokinase Isoforms Are Expressed in Rat Brain

, 2000
Recently, the description of glucokinase mRNA in certain neuroendocrine cells has opened new ways to characterize this enzyme in the rat brain. In this study, we found glucokinase mRNA and a similar RNA splicing pattern of the glucokinase gene product in
Blázquez Fernández, Enrique, Vázquez Pérez, Patricia, Álvarez García, Elvira, Roncero Rincón, Isabel   +3 more
core   +1 more source

Glucokinase and Glucokinase Regulatory Proteins are Functionally Coexpressed before Birth in the Rat Brain

, 2009
Our previous description of functional glucokinase (GK) isoforms and their interactions with glucokinase regulatory protein (GKRP) in adult rat and human brains suggested that both participate in glucose sensing in the central nervous system.
Álvarez, E., Blázquez Fernández, Enrique, Barrio, P.A., Roncero Rincón, Isabel, Sanz Miguel, María Del Carmen   +4 more
core   +1 more source

Expression of glucose transporter isoform GLUT‐2 and glucokinase genes in human brain

, 2004
The glucose transporter isoform-2 (GLUT-2) and glucokinase are considered to be components of a glucose sensor system controlling several key processes, and hence may modulate feeding behaviour. We have found GLUT-2 and glucokinase mRNAs in several brain
Vázquez Pérz, Patricia, Blázquez Fernández, Enrique, Rábano, Alberto, Chowen, Julie A., Álvarez García, Elvira, Roncero Rincón, Isabel, Sanz Miguel, María Del Carmen   +6 more
core   +1 more source

Glucokinase activity in diabetes: too much of a good thing? [PDF]

, 2022
Type 2 diabetes (T2D) is a global health problem characterised by chronic hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised to stimulate insulin release it was initially argued that drugs that stimulate glucokinase ...
Haythorne, Elizabeth A, Lloyd, Matthew, Ashcroft, Frances M   +2 more
core   +1 more source

GENETICS OF YEAST GLUCOKINASE [PDF]

Genetics, 1983
ABSTRACT Mutants of Saccharomyces cerevisiae lacking glucokinase (EC 2.7.1.2) have no discernible phenotypic difference from the wild-type strain; in a hexokinaseless background, however, they are unable to grow on any sugar except galactose. Reversion studies with glucokinase mutants indicate that the yeast S.
P K, Maitra, Z, Lobo
openaire   +2 more sources