Results 11 to 20 of about 31,450 (226)

Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta‐Cell Function [PDF]

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
In the non‐diabetic beta‐cell (top left) activation of glucokinase (bottom left) leads to inhibition of mitochondrial metabolism and thereby impairs insulin secretion. The effect is similar to that of chronic hyperglycaemia as seen in the diabetic beta‐cell (top right).
Matthew Lloyd, Natascia Vedovato, Samuel J. Mullan, Alice Elphick, Aerin J. Dumenil, Chantal Rufer, Alexandra C. Title, Burcak Yesildag, Elizabeth Haythorne, Frances M. Ashcroft   +9 more
wiley   +2 more sources

Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations [PDF]

eLife
Oscillations in insulin secretion, driven by islet Ca2+ waves, are crucial for glycemic control. Prior studies, performed with single-plane imaging, suggest that subpopulations of electrically coupled β-cells have privileged roles in leading and ...
Erli Jin, Jennifer K Briggs, Richard KP Benninger, Matthew J Merrins   +3 more
doaj   +2 more sources

Sugar‐sensing swodkoreceptors and swodkocrine signaling [PDF]

Animal Models and Experimental Medicine
Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules.
Savani Anbalagan
doaj   +2 more sources

Circadian rhythm, glucose metabolism and diabetic complications: the role of glucokinase and the enlightenment on future treatment [PDF]

Frontiers in Physiology
The circadian clock, an innate timing mechanism, governs a variety of physiological activities by producing near-24-h cycles in gene expression. These cycles are reflected in patterns of metabolism and behavior.
Zhijun Zhang, Shuo Wang, Ling Gao
doaj   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex

Translational Neuroscience, 2022
Brain metabolic-sensory targets for modulatory glucose-sensitive endocrine and neurochemical signals remain unidentified. A hypothalamic astrocyte primary culture model was here used to investigate whether glucocorticoid receptor (GR) and noradrenergic ...
Alhamyani Abdulrahman, Napit Prabhat R., Bheemanapally Khaggeswar, Sylvester Paul W., Briski Karen P.   +4 more
doaj   +1 more source

Precision Therapy for a Chinese Family With Maturity-Onset Diabetes of the Young

Frontiers in Endocrinology, 2021
ObjectiveTo determine the pathogenic gene and explore the clinical characteristics of maturity-onset diabetes of the young type 2 (MODY2) pedigree caused by a mutation in the glucokinase (GCK) gene.MethodsUsing whole-exome sequencing (WES), the ...
Juyi Li, Meng Shu, Xiufang Wang, Aiping Deng, Chong Wen, Juanjuan Wang, Si Jin, Hongmei Zhang   +7 more
doaj   +1 more source

Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

Molecular Metabolism, 2018
Objective: Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of key ...
Ali J. Chakera, Paul S. Hurst, Gill Spyer, Emmanuel O. Ogunnowo-Bada, William J. Marsh, Christine H. Riches, Chen-Yu Yueh, S. Pauliina Markkula, Jeffrey W. Dalley, Roger D. Cox, Ian A. Macdonald, Stephanie A. Amiel, Kenneth M. MacLeod, Lora K. Heisler, Andrew T. Hattersley, Mark L. Evans   +15 more
doaj   +1 more source

From glucose sensing to exocytosis: takes from maturity onset diabetes of the young

Frontiers in Endocrinology, 2023
Monogenic diabetes gave us simplified models of complex molecular processes occurring within β-cells, which allowed to explore the roles of numerous proteins from single protein perspective.
Sama Samadli, Sama Samadli, Qiaoli Zhou, Bixia Zheng, Wei Gu, Aihua Zhang   +5 more
doaj   +1 more source