Results 11 to 20 of about 17,223 (183)
Glucokinase and glucokinase activator
Life Metabolism, 2023 Abstract Glucokinase (GK) plays a pivotal role in glucose homeostasis as the glucose sensor in the pancreas and liver. Loss of function of GK results in hyperglycemia, and gain of function causes congenital hyperinsulinemic hypoglycemia.
Li, Changhong +3 more
openaire +2 more sources
A glucokinase-linked sensor in the taste system contributes to glucose appetite
Molecular Metabolism, 2022 Objectives: Dietary glucose is a robust elicitor of central reward responses and ingestion, but the key peripheral sensors triggering these orexigenic mechanisms are not entirely known.
Sandrine Chometton +6 more
doaj +1 more source
Precision Therapy for a Chinese Family With Maturity-Onset Diabetes of the Young
Frontiers in Endocrinology, 2021 ObjectiveTo determine the pathogenic gene and explore the clinical characteristics of maturity-onset diabetes of the young type 2 (MODY2) pedigree caused by a mutation in the glucokinase (GCK) gene.MethodsUsing whole-exome sequencing (WES), the ...
Juyi Li +7 more
doaj +1 more source
Molecular Metabolism, 2018 Objective: Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of key ...
Ali J. Chakera +15 more
doaj +1 more source
Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein [PDF]
International Journal of Molecular Sciences, 2015 Glucokinase (GCK) is the rate-limiting enzyme of liver glucose metabolism. Through protein-protein interactions, glucokinase regulatory protein (GCKR) post-transcriptionally regulates GCK function in the liver, and causes its nuclear localization. However the role of GCK in regulating GCKR localization is unknown.
Jin, Ling +13 more
openaire +3 more sources
From glucose sensing to exocytosis: takes from maturity onset diabetes of the young
Frontiers in Endocrinology, 2023 Monogenic diabetes gave us simplified models of complex molecular processes occurring within β-cells, which allowed to explore the roles of numerous proteins from single protein perspective.
Sama Samadli +5 more
doaj +1 more source
Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice.
PLoS ONE, 2013 Aims/hypothesisGlucose sensing (eg. glucokinase activity) becomes impaired in the development of type 2 diabetes, the etiology of which is unclear. Estrogen can stimulate glucokinase activity, whereas the pervasive environmental pollutant bisphenol A ...
Leigh Perreault +5 more
doaj +1 more source
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
PLoS Pathogens, 2013 Mycobacterium tuberculosis (Mtb) is thought to preferentially rely on fatty acid metabolism to both establish and maintain chronic infections. Its metabolic network, however, allows efficient co-catabolism of multiple carbon substrates.
Joeli Marrero +3 more
doaj +1 more source
Angewandte Chemie, EarlyView.ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann +17 more
wiley +2 more sources
Frontiers in Neuroscience, 2019 Glucose homeostasis is performed by specialized cells types that detect and respond to changes in systemic glucose concentration. Hepatocytes, β-cells and hypothalamic tanycytes are part of the glucosensor cell types, which express several proteins ...
Magdiel Salgado +5 more
doaj +1 more source