Results 31 to 40 of about 40,634 (335)

Drug Import Replacement Is a Perspective Direction of the Development of Russian Economy

Управленческое консультирование, 2018
The development of the domestic pharmaceutical industry as a science-intensive and hightech sector of the country’s economy is, among other things, a pledge of the drug safety of the state, especially in the conditions of a modern complex political ...
K. D. Grigorieva
doaj   +1 more source

A dose-escalation study of HP501, a highly selective URAT1 inhibitor, in male Chinese patients with hyperuricemia

Scientific Reports, 2023
HP501 is a highly selective renal urate transporter 1 (URAT1) inhibitor used for treating hyperuricemia. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of HP501 in male Chinese patients.
Ruilin Ding, Xuehong Deng, Longxia Chen, Yang Zhen, Xinghai Li, Tengqiong Xiong, Yuanhua Zhang, Hong Chen, Xiaojing Hu, Yun Li, Yi Zhou, Feng Jiang, Qing Peng, Xiaojie Wang   +13 more
doaj   +1 more source

Assessing clinical research coordinator knowledge of good clinical practice: An evaluation of the state of the art and a test validation study

Journal of Clinical and Translational Science, 2020
This paper describes the development and validation of a new 32-item test of knowledge of good clinical practice (GCP) administered to 625 clinical research coordinators.
James M. DuBois, Jessica T. Mozersky, Alison L. Antes, Kari Baldwin, Michelle Jenkerson   +4 more
doaj   +1 more source

The need for ‘Good Clinical Practice’ in health care research

South African Family Practice, 2009
Randomised controlled trials form the foundation for ‘evidence-based-medicine’, but the results of such research can be relied upon only if it was conducted according to principles and standards collectively referred to as ‘Good Clinical Practice’ (GCP).
M.H.R. NoorZurani, NorAzah Aziz, Aznida F. Abdul Aziz, Mohd Z. Abd Hamid, Mohazmi Mohamed, Sajaratulnisah Othman, N. Hussein   +6 more
doaj   +1 more source

UV resonance Raman spectroscopy of the supramolecular ligand guanidiniocarbonyl indole (GCI) with 244 nm laser excitation

Beilstein Journal of Organic Chemistry, 2020
Ultraviolet resonance Raman (UVRR) spectroscopy is a powerful vibrational spectroscopic technique for the label-free monitoring of molecular recognition of peptides or proteins with supramolecular ligands such as guanidiniocarbonyl pyrroles (GCPs).
Tim Holtum, Vikas Kumar, Daniel Sebena, Jens Voskuhl, Sebastian Schlücker   +4 more
doaj   +1 more source

Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells

Frontiers in Pharmacology, 2021
Glucocappasalin (GCP), a natural product derived from the seeds of Descurainia sophia (L.) Webb. ex Prantl, exhibits potential antitumor activity in HeLa cervical carcinoma cells.
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi   +9 more
doaj   +1 more source

Evaluation of Ornidazole Tablets Bioequivalence in Chinese Healthy Participants Under Fasted and Fed Conditions Using Pharmacokinetic Parameters

Drugs in R&D
Background and Objective Ornidazole, the third generation of nitroimidazole derivatives after metronidazole and tinidazole, it exerts both bactericidal and antiprotozoal effects.
Yanrong Wang, Yuanyuan He, Weihong Li, Hongmin LI, Liyuan Tang, Xinya Dai, Yingzi Pei, Lijing Gao   +7 more
doaj   +1 more source

Mimicking Block Copolymer Self‐Assembly with One‐Pot Synthesized Polyphosphoester Gradient Copolymers

Advanced Functional Materials, EarlyView.
Degradable Polyphosphoester (PPE) gradient copolymers (GCPs) are synthesized via one‐pot copolymerization. We show that GCPs self‐assemble into nanostructures like polymersomes, effectively mimicking the behavior of traditional BCPs. The gradient strength is key, with softer gradients favoring micelles.
Suna Azhdari, Timo Rheinberger, Ulrich Mansfeld, Yorick Post, Jürgen Linders, Olga Koshkina, André H. Gröschel, Frederik R. Wurm   +7 more
wiley   +1 more source

Reducing Personalization Time and Energy Cost While Walking Outdoors with a Portable Exosuit

Advanced Robotics Research, Volume 2, Issue 1, February 2026.
Rapid Real‐World Optimization! An AF‐based human‐in‐the‐loop optimization strategy rapidly personalizes a portable hip extension exosuit for incline walking. Real‐time Bayesian optimization of assistive force significantly reduces metabolic energy—up to 16.2%—while converging in just 3 min 24 s.
Kimoon Nam, Saikat Sahoo, Yoosun Kim, Dongmin Go, Jeongho Choo, Cheonkyu Park, Seungtae Yang, Giuk Lee   +7 more
wiley   +1 more source

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage

Advanced Science, EarlyView.
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Jianmu Su, Sisheng Zhang, Lidi Liang, Haiyi Bai, Mei Bai, Hanjun He, Yayu Wang, Huan Liu, Xiangxiu Liang, Yu Sun, Hong Wu   +10 more
wiley   +1 more source