First-In-Human Study of Mirogabalin (BM2216) Sustained-Release Tablets: Safety, Tolerability, Pharmacokinetics, Food Effect and Dose Proportionality With Comparison to Mirogabalin Besylate in Healthy Participants. [PDF]
Diabetes Obes MetabABSTRACT Aim To characterise the pharmacokinetics (PKs) and safety of BM2216 sustained‐release (SR) tablets after single‐dose oral administration under fasted/fed conditions in healthy participants, assess the effect of food and dose proportionality, and compare the single and multiple‐dose PK of BM2216 SR tablets with mirogabalin besylate tablets to ...
Song P +6 more
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Evaluating the Impact of CYP1A2 Inhibition on the Pharmacokinetics of Savolitinib: A Phase 1 Open-Label Study. [PDF]
Pharmacol Res PerspectABSTRACT Savolitinib is an oral, potent, selective CNS‐penetrant MET‐tyrosine kinase inhibitor that in vitro studies indicate is metabolized by cytochrome P450 (CYP) enzymes, including CYP1A2, and by non‐CYP enzymes, such as aldehyde oxidase (AO). Savolitinib primary metabolites, M2 and M3, are formed mainly by CYP1A2 and AO, respectively. This Phase 1,
Miah K +7 more
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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells [PDF]
The Scientific World Journal, 2013 Although the combination of herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) with ganciclovir (GCV) has been shown as a promising suicide gene treatment strategy for glioma, the almost immunodepressive dose of GCV required for its adequate in ...
Lei-qing Li +5 more
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Performance of Robust GCV and Modified GCV for Spline Smoothing [PDF]
Scandinavian Journal of Statistics, 2011 Abstract. While it is a popular selection criterion for spline smoothing, generalized cross‐validation (GCV) occasionally yields severely undersmoothed estimates. Two extensions of GCV called robust GCV (RGCV) and modified GCV have been proposed as more stable criteria. Each involves a parameter that must be chosen, but the only guidance has come from
Lukas, M.A. +2 more
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Practical use of robust GCV and modified GCV for spline smoothing [PDF]
Computational Statistics, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Lukas, M.A. +2 more
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GCVS problems with flare stars [PDF]
International Astronomical Union Colloquium, 1995 The astrometric aspect of cataloguing variable stars becomes more and more important. During the past thirty years there has been approximately an three-fold increase of the number of known variables; now the rate of new discoveries becomes extremely high, and we may expect a new twofold increase in a couple of years due to discoveries made with space ...
Elena V. Kazarovets, Nikolai N. Samus
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Large-Scale Surveys and the GCVS [PDF]
International Astronomical Union Colloquium, 2000 AbstractWe briefly discuss changes in the work on the General Catalogue of Variable Stars (GCVS) necessary in the era of automatic variability discoveries and large-scale surveys.
N. N. Samus +2 more
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Gene conversion-like events in the diversification of human rearranged IGHV3-23*01 gene sequences
Frontiers in Immunology, 2012 Gene conversion (GCV) as a mechanism of immunoglobulin diversification is well established in a few species. However, definitive evidence of GCV-like events in human immunoglobulin genes is scarce. GCV is mediated by activation-induced cytidine deaminase
Bhargavi eDuvvuri, Gillian E Wu
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Case Reports in Genetics, 2015 To date, few cases of 3p proximal interstitial deletions have been reported and the phenotype and genotype correlation is not well understood. Here, we report a new case of a 3p proximal interstitial deletion.
Ana Belén de la Hoz +5 more
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Late emergence of A594V and L595W mutations related to ganciclovir resistance in a patient with HCMV retinitis and long-term HIV progression [PDF]
Brazilian Journal of Medical and Biological Research, 2015 The emergence of ganciclovir (GCV) resistance during the treatment of human cytomegalovirus (HCMV) infection is a serious clinical challenge, and is associated with high morbidity and mortality.
S.N. Slavov +7 more
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