Results 71 to 80 of about 8,557 (189)

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Automatic computation of hierarchical biquadratic smoothing splines with minimum GCV

Computers & Geosciences, 2006
A computationally efficient numerical strategy for fitting approximate minimum GCV bivariate thin plate smoothing splines to large noisy data sets was developed. The procedure discretises the bivariate thin plate smoothing spline equations using biquadratic B-splines and uses a nested grid SOR iterative strategy to solve the discretised system.
Penelope A. Hancock, Michael F. Hutchinson   +1 more
openaire   +3 more sources

Rising, falling, stalling: complex biodiversity trajectories in English rivers

Ecography, Volume 2026, Issue 10, October 2026.
Freshwater ecosystems face intense anthropogenic pressures. Yet in parts of Europe, including the UK, studies have documented widespread increases in macroinvertebrate diversity following investments to improve water quality. More recent analyses, however, suggest that these gains have slowed, plateaued, or even reversed. Despite increasing recognition
Mansi Mungee, Martin Wilkes, Vicky A. Bell, William E. Kunin, Christopher Hassall, Lee E. Brown   +5 more
wiley   +1 more source

Morphological, Phytochemical, and Molecular Characterization of Advanced Tomato Lines Under Heat Stress Conditions

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT Heat stress severely limits tomato growth, yield, and biochemical stability, highlighting the need for thermotolerant genotypes. This study evaluated six advanced tomato lines using morphological, biochemical, genetic, and molecular analyses under heat stress conditions.
Haidar Anwar Arkwazee, Salam Mahmud Sulaiman, Kamaran Salh Rasul, Hawar Halshoy, Shwana Ahmed Braim   +4 more
wiley   +1 more source

Conserved Asp233–Asp246 hydrogen bond modulates active site dynamics in class A β‐lactamases

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Rigid enzymes catalyze chemical reactions by stabilizing the transition state through a specific conformation. Catalytic residues are precisely positioned, and enzyme dynamics are kept to a minimum. It is thought that conserved residues around the active site (second‐shell residues) play a crucial role in positioning catalytic residues. Asp233
Cristina V. Lopez‐Gallego, Monika Timmer, Jocelyne Vreede, Marcellus Ubbink   +3 more
wiley   +1 more source

Genetic parameters, character association and path analysis for fruit yield and its component characters in guava (Psidium guajava L.)

Electronic Journal of Plant Breeding, 2019
The present investigation was conducted to estimate genetic parameters, correlations and path coefficients from different traits of nine genotypes in guava. The genotypes exhibited a wide range of variability for all the characters studied.
Navjot Gupta and, Amardeep Kour
doaj   +1 more source

RR Lyrae Stars In The GCVS Observed By The Qatar Exoplanet Survey

, 2014
Peer ...
Bramich, Daniel Martyn, Alsubai, Khalid Abdulla T, Arellano Ferro, A., Parley, Neil, Cameron, Andrew Collier, Horne, Keith Douglas, Pollacco, D., West, R. G.   +7 more
openaire   +3 more sources

Renal maturation and catch-up clearance of ganciclovir in a preterm neonate: Bayesian pharmacokinetic analysis using a population model

Journal of Pharmaceutical Health Care and Sciences
Background Congenital cytomegalovirus (CMV) infection is a major cause of neonatal morbidity. However, optimizing ganciclovir (GCV) dosing in preterm infants is complicated by immature renal function and developmental pharmacokinetics.
Katsuya Kata, Satomi Inomata, Mitsuru Nishikawa, Haruka Ide, Kentaro Nakamura, Taketoshi Yoshida, Masato Taguchi   +6 more
doaj   +1 more source

Estimasi Produksi Beras dengan Estimator Campuran Spline Truncated – Kernel di Jawa Timur

Jambura Journal of Mathematics
This study aims to apply a nonparametric regression model using a mixed estimator of Truncated Spline and Kernel to estimate Rice Production in East Java Province.
Andrea Tri Rian Dani, Fachrian Bimantoro Putra, I Nyoman Budiantara, Vita Ratnasari   +3 more
doaj   +1 more source

Hay Fever Symptom Burden From Grass Pollen: Implications for Public Health Warning Thresholds

GeoHealth, Volume 10, Issue 10, October 2026.
Abstract This study quantifies the lagged association between grass pollen exposure and the onset of allergic rhinitis (AR) symptoms, including differences between asthmatic and non‐asthmatic subgroups. Data included 114,834 self‐reported AR symptoms collected from 25,194 uniquely identified users of a smartphone application.
Max J. Tyler, Darsy Darssan, Edwin R. Lampugnani, Nicholas J. Osborne   +3 more
wiley   +1 more source