Results 181 to 190 of about 13,346 (214)

Variable Expression of the Disialoganglioside GD2 in Breast Cancer Molecular Subtypes

Cancers, 2021
The disialoganglioside GD2 is a tumor-associated antigen that may allow for the application of targeted immunotherapies (anti-GD2 antibodies, GD2 CAR T cells) in patients with neuroblastoma and other solid tumors.
Ramona Erber, Sareetha Kailayangiri, Hanna Huebner   +2 more
exaly   +3 more sources

GD2 Expression in Medulloblastoma and Neuroblastoma for Personalized Immunotherapy: A Matter of Subtype

Cancers, 2022
Neuroblastoma (NBL) and medulloblastoma (MB) are aggressive pediatric cancers which can benefit from therapies targeting gangliosides. Therefore, we compared the ganglioside profile of 9 MB and 14 NBL samples by thin layer chromatography and mass ...
Claudia Paret, Sara Ersali, Larissa Seidmann   +2 more
exaly   +2 more sources

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Mimotopes of the disialoganglioside GD2 elicit anti-GD2 antibodies recognising GD2 on melanoma cells

Journal of Clinical Oncology, 2006
12505 Background: The disialoganglioside GD2, a carbohydrate antigen, is expressed on all tumors of neuroectodermal origin, including melanoma, sarcoma, neuroblastoma and small cell lung cancer. Due to its specific expression on tumor surfaces, GD2 is an attractive target for immunotherapy.
K. H. Brämswig, A. B. Riemer, E. Förster-Waldl, A. Pollak, C. C. Zielinski, H. Pehamberger, H. N. Lode, O. Scheiner, E. Jensen-Jarolim   +8 more
openaire   +1 more source

Abstract 5115: Novel humanized anti-GD2 antibody inhibits GD2-mediated immunosuppression by targeting GD2+ breast cancer stem-like cells

Cancer Research, 2023
Abstract Background: Breast cancer stem-like cells (BCSCs) are reported to be a major contributing factor for tumor growth and chemotherapy resistance in triple-negative breast cancer (TNBC). We reported that the disialoganglioside GD2 is highly expressed on BCSCs and that targeting GD2 with dinutuximab (chimeric anti-GD2 antibody) in ...
Vivek Anand, Venkatesh Hegde, Maryam Siddiqui, Anudishi Tyagi, Bolutyfe Oderinde, Mario Marcondes, Willem Overwijk, Venkata Lokesh Battula   +7 more
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Fluorescent GD2 analog for single-molecule imaging

Glycoconjugate Journal, 2023
Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe.
Yamaguchi, Eriko, Komura, Naoko, Tanaka, Hide-Nori, Imamura, Akihiro, Ishida, Hideharu, Groux, Sophie, Mühlenhoff, Martina, Suzuki, Kenichi G. N., Ando, Hiromune   +8 more
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Shedding of GD2 ganglioside in patients with retinoblastoma

International Journal of Cancer, 1993
AbstractRetinoblastoma is a rare tumor of the young child with an intraocular localization that leads to certain problems of diagnosis. With the aim of defining a biochemical marker—which is still lacking for this disease—the gangliosides of a pool of fresh retinoblastoma tumors were analyzed.
J, Portoukalian, M J, David, P, Gain, M, Richard   +3 more
openaire   +2 more sources

Anti-GD2 strategy in the treatment of neuroblastoma

Drugs of the Future, 2010
The prognosis for advanced neuroblastoma remains poor with high risk of recurrence after consolidation. Therapies based on monoclonal antibodies that specifically target disialoganglioside GD2 on tumor cells are improving treatment results for high-risk neuroblastoma.
Richard K, Yang, Paul M, Sondel
openaire   +2 more sources

On the absence of superconductivity in Gd2−xCexCuO4

Physica C: Superconductivity, 1994
Abstract Although electron-doped superconductivity is readily achieved in Ln 2− x Ce x CuO 4 for Ln=(La, Nd), Pr, Nd, Sm, and Eu, the Ln=Gd member remains to be a notable exception in the series. Whether or not the weak ferromagnetism observed in Gd 2− x Ce x CuO 4 is responsible for the suppression of superconductivity needs to be clarified.
A. Manthiram, Y.T. Zhu
openaire   +1 more source

Search for superconductivity in Gd2−Ce Sr2Cu2TiO

Solid State Communications, 1998
Abstract We report the results of electrical resistivity (ρ) measurements on the oxides, Gd2−xCexSr2Cu2TiOy (x=0.0, 0.05, 0.5 and 1.0), prepared in air, inert and oxygen atmospheres, in the temperature interval 13–300 K in order to search for superconductivity, predicted by Blackstead et al. [1] .
E. Sudhakar Reddy, P.V. Patanjali, R. Vijayaraghavan, E.V. Sampathkumaran, R. Pinto   +4 more
openaire   +1 more source

Abstract 5697: EZH2 inhibition upregulates GD2 to enhance anti-GD2 immunotherapy in Ewing sarcoma

Cancer Research
Abstract Introduction: Ewing sarcoma (ES) is a rare and aggressive malignancy of the bones and soft tissue for which substantial improvements in treatment options are desperately needed. ES cells heterogeneously express GD2, a surface marker for which there are targeted immunotherapies that are
Kenzie Wells, Kimberly Q. McKinney, Kaitlyn H. Smith, Poornima Gourabathini, Jeffrey Huo, Erin M. Trovillion, Javier Oesterheld   +6 more
openaire   +1 more source