Results 51 to 60 of about 732,678 (244)
Elimination of Mn3Ga with Low Crystal Symmetry in Alloying Mn-Ga by Ge Addition
Journal of Advanced Materials in Engineering, 2016 In this paper, milling was investigated as a method for production of Mn-Ga binary alloys and the effect of milling process on phase formation of Mn:Ga samples with 2:1 and 3:1 ratio within 1, 2 and 5 hour milling times was studied.
F. Nazari +3 more
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Metalliferous jurassic rocks of the Fan-Y agnob syneclise (Central Tajikistan)
Известия высших учебных заведений: Геология и разведкаBackground. The Fan-Yagnob syneclise is an imposed structure within the Hercynian Zeravshan-Gissar zone. It formed on a Paleozoic folded basement as series of sedimentary rocks from T3 to N1, including Jurassic, Cretaceous, and Paleogene terrigenous ...
M. Saymudasiri, A. K. Litvinenko
doaj +1 more source
Furusato and Emotional Pilgrimage: Ge Ge Ge no Kitaro and Sakaiminato
Japanese Journal of Religious Studies, 2016 The Japanese Journal of Religious Studies is a peer-reviewed journal registered as an Open Access Journal with all the contents freely downloadable. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher
openaire +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation
Nature Communications, 2019 Stimulation of peripheral nerve activity may be used to treat metabolic and inflammatory disorders, but current approaches need implanted devices. Here, the authors present a non-invasive approach, and show that ultrasound-mediated stimulation can be ...
Victoria Cotero +19 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source