Results 61 to 70 of about 732,678 (244)

Ghost Loss to Question the Reliability of Training Data

IEEE Access, 2020
Supervised image classification problems rely on training data assumed to have been correctly annotated; this assumption underpins most works in the field of deep learning.
Adrien Deliege, Anthony Cioppa, Marc Van Droogenbroeck   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Oxide-assisted crack growth in hold-time low-cycle-fatigue of single-crystal superalloys

MATEC Web of Conferences, 2014
Compressive hold-time low-cycle fatigue is one of the important damage modes in Ni-based superalloy hot-gas path components. In strain controlled LCF, the compressive hold typically degrades fatigue life significantly due to creep relaxation and the ...
Suzuki Akane, Gao Yan, Lipkin Don, Singhal Anjali, Krug Matthew, Konitzer Douglas, Almer Jonathan, Pollock Tresa, Bewlay Bernard   +8 more
doaj   +1 more source

Modeling and Experimental Characterization of an Electromagnetic Energy Harvester for Wearable and Biomedical Applications

IEEE Access, 2020
This work presents the modeling and the experimental validation of a linear electromagnetic energy harvester (EMEH) actuated by random low-g external acceleration or by a very slow imposed movement.
G. Digregorio, H. Pierre, P. Laurent, J.-M. Redoute   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pseudo GE-Algebras as the Extension of GE-Algebras

Kragujevac Journal of Mathematics
In this paper, the notion of a pseudo GE-algebra as an extension of a GE-algebra is introduced. Basic properties of pseudo GE-algebras are described. The concepts of strong pseudo BE-algebra, good pseudo BE-algebra, good pseudo GE-algebra, and the relationship between them are established.
Bandaru, Ravikumar, Rezaei, Akbar, Saeid, Arsham Borumand, Jun, Young Bae   +3 more
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Decipher-MR: a vision-language foundation model for 3D MRI representations

npj Digital Medicine
Magnetic Resonance Imaging is a critical imaging modality in clinical diagnosis and research, yet its complexity and heterogeneity hinder scalable, generalizable machine learning.
Zhijian Yang, Noel DSouza, Istvan Megyeri, Xiaojian Xu, Amin Honarmandi Shandiz, Farzin Haddadpour, Krisztian Koos, Laszlo Rusko, Emanuele Valeriano, Bharadwaj Swaminathan, Lei Wu, Parminder Bhatia, Taha Kass-Hout, Erhan Bas   +13 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Birds of the Entella river (Genoa, Italy): a qualitative assessment of bird diversity in an urbanizing biotope, with implications for management and conservation

Rivista Italiana di Ornitologia - Research in Ornithology, 2019
This work presents the first assessment of the birds of the Entella river (Genoa, Liguria), a small wetland embedded in an urbanized matrix. Data were collected through standardized in situ censuses from April 2012 to June 2017 and integrated with ...
Andrea Simoncini, Daniela Papi, Enrico Ruggeri   +2 more
doaj   +1 more source