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TRIM59 promotes gefitinib resistance in EGFR mutant lung adenocarcinoma cells
Life Sciences, 2019The relationship between TRIM59 and drug resistance is elusive despite of its multiple uncovered roles in human cancers. Here we aimed to characterize the expression status of TRIM59 in gefitinib-resistant EGFR mutant lung adenocarcinoma cells and elucidate its mechanism underlying the drug resistance.Gefitinib-resistant cell lines were established by ...
Zhilei, Cui +8 more
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EGFR tyrosine kinase inhibitor ZZC4 overcomes acquired resistance to gefitinib
Toxicology and Applied PharmacologyDespite the tremendous progress of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) development, acquired resistance mechanisms have limited their efficacy in treating non-small cell lung cancer (NSCLC). To overcome these limitations, novel EGFR-TKIs are needed. In our previous study, we presented ZZC4 as a potent EGFR-TKI.
Mawusse K I, Attiogbe +7 more
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Elucidating Mechanisms of Gefitinib Resistance that Instigate Cancer Progression
2018In recent years, cancer treatments have progressed substantially. However, the tumor microenvironment is dynamic and continuously evolving thereby resulting in decreased efficacy to therapies, and resistant cancer cells. The development of drug resistance in cancer patients may potentially trigger or instigate disease progression in the presence of ...
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miR-124 modulates gefitinib resistance through SNAI2 and STAT3 in non-small cell lung cancer
Journal of Huazhong University of Science and Technology [Medical Sciences], 2016Yu Deng
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