Results 111 to 120 of about 98,417 (285)

The complement C3a/C3aR pathway is associated with treatment resistance to gemcitabine-based neoadjuvant therapy in pancreatic cancer

Computational and Structural Biotechnology Journal
Gemcitabine is a standard first-line drug for pancreatic cancer chemotherapy. Nevertheless, gemcitabine resistance is common and significantly limits its therapeutic efficacy, impeding advancements in pancreatic cancer treatment. In this study, through a
Saimeng Shi, Longyun Ye, Kaizhou Jin, Xianjun Yu, Duancheng Guo, Weiding Wu   +5 more
doaj   +1 more source

Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor

, 2012
Gemcitabine is indicated in combination with cisplatin as first-line therapy for solid tumours including non-small cell lung cancer (NSCLC), bladder cancer and mesothelioma.
FARDOD O’KELLY, Nikolaidis, Georgios, ARMELLE MEUNIER, DONAL HOLLYWOOD, Dockry, Éilis, O'Byrne, Kenneth J., TOMAS J. EKSTRÖM, KENNETH J. O’BYRNE, MALIN ALMGREN, GEORGIOS NIKOLAIDIS, ANTOINETTE S. PERRY, Perry, Antoinette S., ANNE-MARIE BAIRD, STEVEN G. GRAY, Gray, Steven G., Baird, Anne-Marie, Almgren, Malin, Ekström, Tomas J., Hollywood, Donal, EILIS DOCKRY, O'Kelly, Fardod, Meunier, Armelle   +21 more
core   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma

, 2013
Dao-Jun Gong,1 Jia-Min Zhang,1 Min Yu,1 Bo Zhuang,1 Qing-Qu Guo21Department of Hepatobiliary-Pancreatic Surgery, Jinhua Hospital of Zhejiang University, Jinhua, People's Republic of China; 2Department of Surgery, Second Affiliated Hospital of ...
Zhang JM, Yu M, Gong DJ, Guo QQ, Zhuang B   +4 more
core  

Incidence and Determinants of Steatotic Liver Disease after Pancreaticoduodenectomy: A Systematic Review and Meta‐Analysis

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Steatotic liver disease (SLD) is an unrecognized complication after pancreaticoduodenectomy (PD) and may affect nutrition and long‐term recovery. This meta‐analysis estimated the incidence of SLD after PD and identified its clinical and surgical risk factors.
Ronnakorn Kongsakon, Wasit Wongtrakul, Khemajira Karaketklang, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya   +4 more
wiley   +1 more source

Independent Prognostic Value of Natural Tooth Count Versus Posterior Teeth Occlusion in Resected Pancreatic Cancer

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Prognostic significance of preoperative patient‐related factors, including oral health status, in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We evaluated the association between preoperative factors—particularly oral health parameters—and long‐term survival after curative PDAC resection.
Kaoru Seo, Kenichiro Uemura, Kenjiro Okada, Hiromi Nishi, Tatsuaki Sumiyoshi, Ryuta Shintakuya, Yoshiaki Murakami, Hiroyuki Kawaguchi, Shinya Takahashi   +8 more
wiley   +1 more source

Comparison the %IR between gemcitabine and gemcitabine plus cisplatin.

, 2019
Comparison the %IR between gemcitabine and gemcitabine plus cisplatin.
Poramate Klanrit (7365617), Attapol Titapun (7365620), Watcharin Loilome (130145), Prakasit Sa-ngiamwibool (7365626), Nisana Namwat (816276), Narong Khuntikeo (415025), Apiwat Jarearnrat (7365623), Anchalee Techasen (816277), Manida Suksawat (7365614), Jutarop Phetcharaburanin (2618605)   +9 more
core   +1 more source

Development and Validation of Nomogram Predicting Survival in Resectable Gallbladder Cancer

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Gallbladder cancers (GBCs) are aggressive tumors with limited improvement in outcomes over decades. Accurate prediction of survival is crucial for tailored treatment and improved outcomes. Objective To develop a nomogram predicting overall survival (OS) in resectable GBCs.
Shraddha Patkar, Tanvi M. Shah, Mufaddal Kazi, Sadhana Kannan, Gurudutt Varty, Vikas Ostwal, Anant Ramaswamy, Prabhat Bhargav, Prajakta Barve, Mahesh Goel   +9 more
wiley   +1 more source

Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Wang, X, Jing Chen, Fan Yan, Xin, W, He Ren, Yan, F, Qian, D, Li, J, Hao, J, Wen Xin, Dong Qian, Chongbiao Huang, Jia, L, Song Gao, Jing Li, Chen, J, Huang, C, Zhao, T, Ren, H, Gao, S, Li Jia, Jihui Hao, Tiansuo Zhao, Xiuchao Wang   +23 more
core   +1 more source

Dynamic Prognostic Nutritional Index With Circulating Tumor DNA Predicts Survival in Localized Pancreatic Ductal Adenocarcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives To evaluate the prognostic significance of baseline and longitudinal changes in prognostic nutritional index (PNI) in localized pancreatic ductal adenocarcinoma (PDAC) and to assess the complementary prognostic value of PNI with tumor burden measured by circulating tumor DNA (ctDNA).
Alex Horowitz, Claire Shen, Dominic J. Vitello, Madison Cox, Amy Wells, Krishay Sridalla, David J. Bentrem, Qiang Zhang, Ishan Roy, Akhil Chawla   +9 more
wiley   +1 more source