Results 171 to 180 of about 66,449 (275)

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Molecular subtype concordance and metastatic patterns in muscle‐invasive bladder cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.
Abstract Molecular subtypes are potential prognostic and predictive tools in muscle‐invasive bladder cancer (MIBC). However, subtype concordance between primary tumors and metastases, as well as subtype‐specific differences in metastatic patterns, remain poorly characterized.
Csilla Olah, Dániel Juhász, Melinda Váradi, Henning Reis, Mulham Al‐Nader, Osama Mahmoud, Barbara T. Grünwald, Viktor Grünwald, Boris Hadaschik, Péter Nyirády, Tibor Szarvas   +10 more
wiley   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, Volume 38, Issue 26, 8 May 2026.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors

, 2016
鹿児島大学
openaire   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Preoperative FAN score predicts survival outcomes after radical cystectomy for bladder cancer

BJUI Compass, Volume 7, Issue 5, May 2026.
Abstract Objective This study aimed to evaluate whether the preoperative FAN score—composed of the fibrosis‐4 (Fib‐4) index, albumin–bilirubin (ALBI) score and neutrophil–lymphocyte ratio (NLR)—predicts recurrence‐free, cancer‐specific and overall survival after radical cystectomy for bladder cancer.
Yu Ishizuya, Atsunari Kawashima, Shimpei Yamashita, Takeshi Ujike, Tetsuya Takao, Osamu Miyake, Hiroki Osaki, Hiromu Horitani, Toshichika Iwanishi, Tsuyoshi Takada, Yuta Oki, Takahiro Yoshida, Makoto Matsushita, Ken‐Ichi Kakimoto, Akira Nagahara, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Koji Hatano, Yasuo Kohjimoto, Isao Hara, Norio Nonomura   +21 more
wiley   +1 more source

ENO1-mediated deoxycytidine synthesis and gemcitabine resistance by stabilizing RRM2 in pancreatic cancer. [PDF]

Cell Death Dis
Li Y, Wang H, Chen L, Gong Y, Zheng D, Li F, Wu C, He Z, Yu C.   +8 more
europepmc   +1 more source

Clinicopathological and Prognostic Implications of Epithelial‐to‐Mesenchymal Transition‐Related Immunohistochemical Markers in Resectable Pancreatic Cancer: A Retrospective Longitudinal Study

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) is the sixth leading cause of global cancer death. The process of epithelial‐to‐mesenchymal transition (EMT) is a key driver of early progression and metastasis in PDAC. Aim Our study aimed to explore the correlation between the expression of EMT markers and survival outcomes.
Ahmad Machmouchi, Lama Zahreddine, Jessica Aoun, Noura Abbas, Maya Charafeddine, Laudy Chehade, Charbel Elias, Ziad El Husseini, Sally Temraz, Deborah Mukherji, Mohamad Khalife, Walid Faraj, Amar Zaidan, Nayrose Kadi, Ayman Tawil, Ali Shamseddine   +15 more
wiley   +1 more source

Extracellular Vesicle-Mediated Regulation of H3C14 Contributes to Gemcitabine Resistance in Bladder Cancer. [PDF]

J Extracell Vesicles
Huang CS, Yu DS, Jiang SS, Wu YS, Ho JY, Yu CP.   +5 more
europepmc   +1 more source