Results 191 to 200 of about 2,243,647 (283)

TPI1 enhances gemcitabine resistance in bladder cancer by promoting autophagy through activating Beclin-1. [PDF]

Cell Death Dis
Wang C, Li K, Wan S, Chen S, Liu S, Yang L.   +5 more
europepmc   +1 more source

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
Metabolic reprogramming in cancer stem cells: lipid flux, mitochondrial plasticity, and therapeutic resistance. Lipid metabolism in CSCs: de novo lipogenesis, CD36 uptake, FAO, lipid droplets, and membrane remodeling. Mitochondrial dynamics in CSC survival: fusion, fission, mitophagy, OXPHOS switching, and ROS regulation.
Daniel Ejim Uti, Esther Ugo Alum, Josephine E. Egbung, Zuhair M. Mohammedsaleh, Manpreet Kaur, Kranti Kiran Reddy Ealla   +5 more
wiley   +1 more source

SLC6A14-mediated glutamine promotes SYTL4-CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer. [PDF]

Exp Mol Med
Kang HW, Kim JH, Jeong JW, Fang S, Yun WG, Jung HS, Kwon W, Jang JY, Kim HJ, Park JS.   +9 more
europepmc   +1 more source

Recent Advances in Microwave and Ultrasound Assisted Synthesis of Quinoline Derivatives as Anticancer Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Green microwave‐ and ultrasound‐assisted synthesis enables the rapid, sustainable preparation of quinoline‐based anticancer agents with improved reaction efficiency, higher yields, and enhanced biological activity. ABSTRACT Quinoline derivatives represent a privileged class of heterocyclic compounds with remarkable structural diversity and broad ...
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree B V, Vipin K. Pandey, Shourya Pratap   +5 more
wiley   +1 more source

Clinical Benefit of Pembrolizumab in Lynch Syndrome‐Associated Advanced Ovarian Cancer With Germline MSH6 Variant: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first‐line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.
Tomomi Yokozawa, Sayako Nakagawa, Yukio Suzuki, Aya Tokinaga‐Uchiyama, Katsuyuki Konnai, Hiroto Narimatsu, Yukihiko Hiroshima, Haruya Saji   +7 more
wiley   +1 more source

USP43 promotes gemcitabine resistance by regulating cholesterol homeostasis through E2F1 stabilization in bladder cancer. [PDF]

J Exp Clin Cancer Res
Li M, Liu T, Shi J, Zhou F, Deng Z, Luo Y, Tu S, Jiang W, Wang G, Qian K, Zhang Y, Xiao Y, Wang X, Liu T, Ju L.   +14 more
europepmc   +1 more source

AZD6738 (Ceralasertib) Enhances Trifluridine's Antitumor Effect in 5‐FU–Resistant Colorectal Cancer Cells

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Resistance to 5‐fluorouracil (5‐FU) remains a major obstacle in colorectal cancer (CRC) treatment. Trifluridine (FTD), the active component of TAS‐102, exerts cytotoxicity through DNA incorporation and reportedly remains active in 5‐FU‐resistant tumors, though with limited clinical efficacy.
Shuhei Uehara, Takuya Suzuki, Junki Kato, Hiroyuki Asai, Akira Kato, Shinnosuke Harata, Hajime Ushigome, Yushi Yamakawa, Takahisa Hirokawa, Hiroki Takahashi, Yoichi Matsuo, Shuji Takiguchi   +11 more
wiley   +1 more source

Intratumoral <i>Enterobacter hormaechei</i> drives gemcitabine resistance in pancreatic cancer via <i>cdd</i> _L-mediated drug inactivation. [PDF]

Imeta
Peng JF, Li M, Niu T, Li J, Niu W, Zheng M, Ji Q, Li C, Shao C, Ding K.   +9 more
europepmc   +1 more source

Comprehensive Profiling of ac4C RNA Modification Identifies CERCAM in Cancer‐Associated Fibroblasts as a Key Prognostic and Microenvironmental Regulator in Colorectal Cancer

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background N4‐acetylcytidine (ac4C) RNA modification has emerged as a critical epigenetic regulator in tumorigenesis and progression. However, the comprehensive landscape of ac4C modification in colorectal cancer (CRC), particularly its orchestration of the tumor microenvironment (TME) and stromal crosstalk, remains largely unexplored.
Yang Xia, Jialin Dai, Xinyi Zhou, Ruige Zhang   +3 more
wiley   +1 more source

Positive Feedback Loop of Histone Lactylation-Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance. [PDF]

Adv Sci (Weinh)
Huang XT, Chen J, Zhu EL, Ma MJ, Yu YY, Zhu YQ, Ye JY, Xie JZ, Zhao ZY, Yin XY.   +9 more
europepmc   +1 more source