Results 201 to 210 of about 66,449 (275)

USP43 promotes gemcitabine resistance by regulating cholesterol homeostasis through E2F1 stabilization in bladder cancer. [PDF]

J Exp Clin Cancer Res
Li M, Liu T, Shi J, Zhou F, Deng Z, Luo Y, Tu S, Jiang W, Wang G, Qian K, Zhang Y, Xiao Y, Wang X, Liu T, Ju L.   +14 more
europepmc   +1 more source

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, Volume 117, Issue 5, Page 1273-1285, May 2026.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The thiocarbenium ion rearrangement of 3‐dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against drug‐resistant cancers, collected from the deep‐ocean along the Aleutian Islands.
Cody F. Dickinson, Abhay Potluri, Alison M. Bland, Samuel M. Flipse, George S. Hanna, Ryan T. Wagner, Keith D. Robertson, Thai H. Ho, Daniel J. Sprague, Gerald R. Hoff, Robert P. Stone, Marcus A. Tius, Dean J. Tantillo, Mark T. Hamann   +13 more
wiley   +2 more sources

Microbiome Modulation with <i>Lactobacillus rhamnosus</i> GG Potentiates Curcumin's Efficacy in Reversing Gemcitabine Resistance of Gallbladder Cancer through Gut Microbiota-PI3K/AKT Axis. [PDF]

J Microbiol Biotechnol
Li Y, Niu S, Wang H, Li J.
europepmc   +1 more source

CALR/HIF‐1α Positive Feedback Loop Drives CALR Upregulation to Promote EMT‐Mediated Bladder Cancer Progression via ROS/AKT Axis

Cancer Science, Volume 117, Issue 5, Page 1286-1302, May 2026.
This study first found that the high expression of CALR is due to a novel positive feedback loop with HIF‐1α in the tumor microenvironment: CALR stabilizes HIF‐1α protein, while HIF‐1α transcriptionally upregulates CALR expression, thereby self‐sustaining its high expression levels in BLCA.
Xintao Tian, Yue Liu, Zhiyuan Mi, Ye Liang, Zhao Zhang, Xiaocheng Ma, Huiqing Jia, Yuxuan Cao, Zhijuan Liang, Shaonan Yang, Guofeng Ma, Haitao Niu   +11 more
wiley   +1 more source

Role and molecular mechanisms of hypoxia-derived exosomal miR-301a on gemcitabine resistance in pancreatic cancer. [PDF]

Oncol Lett
Qu W, Tan W, Ye M, Tang W, Zhang L, Luo G.   +5 more
europepmc   +1 more source

Defining the tumor microenvironment of non‐small cell lung cancer

Immunology &Cell Biology, Volume 104, Issue 5, Page 499-518, May‐June 2026.
The tumor microenvironment (TME) in non‐small cell lung cancer is highly heterogeneous, both at a patient level and tumor microenvironment resolution. Defining the tumor microenvironment from patient‐responders and non‐responders will aid in the development of targeted therapeutics specific for each individual patient.
Kidane Siele Embaye, Tony Blick, Vahid Yaghoubi Naei, Ken O'Byrne, Brett G. M. Hughes, Arutha Kulasinghe   +5 more
wiley   +1 more source

F41, a Novel Fungal Indole-Diterpenoid, Overcomes Gemcitabine Resistance in Pancreatic Cancer by Inducing ER Stress. [PDF]

Int J Mol Sci
Gao Z, Liu L, Xu Y, Zhao C, Zhao X, Zhao T, Che Y, Zhao W.   +7 more
europepmc   +1 more source

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

MicroRNA-125b inhibits apoptosis and increases gemcitabine resistance by downregulating the expression of BAK1 in pancreatic ductal adenocarcinoma. [PDF]

Transl Cancer Res
Sun J, Zhao Z, Yao Y, Zhang J, Yao R, Hu Z.   +5 more
europepmc   +1 more source