Results 191 to 200 of about 3,125,328 (279)

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, Volume 13, Issue 3, 14 January 2026.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

F41, a Novel Fungal Indole-Diterpenoid, Overcomes Gemcitabine Resistance in Pancreatic Cancer by Inducing ER Stress. [PDF]

Int J Mol Sci
Gao Z, Liu L, Xu Y, Zhao C, Zhao X, Zhao T, Che Y, Zhao W.   +7 more
europepmc   +1 more source

Tables S1-S13 from Integrative Genomic Analysis of Gemcitabine Resistance in Pancreatic Cancer by Patient-derived Xenograft Models

, 2023
Gang Yang, Wenfang Guan, Zhe Cao, Wenbo Guo, Guangbing Xiong, Fangyu Zhao, Mengyu Feng, Jiangdong Qiu, Yueze Liu, Michael Q. Zhang, Lei You, Taiping Zhang, Yupei Zhao, Jin Gu   +13 more
openalex   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

MicroRNA-125b inhibits apoptosis and increases gemcitabine resistance by downregulating the expression of BAK1 in pancreatic ductal adenocarcinoma. [PDF]

Transl Cancer Res
Sun J, Zhao Z, Yao Y, Zhang J, Yao R, Hu Z.   +5 more
europepmc   +1 more source

GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma [PDF]

Tianyi Zhu, Qianwen Yang, Xiaozhe Qian, Xudong Wu, Jianchen Fang, Yuli Lin, Yukuan Feng, Jian Gao, Q. Xia   +8 more
openalex   +1 more source

Data from Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer

, 2023
Ignacio Garrido‐Laguna, Maria Uson, N.V. Rajeshkumar, Aik Choon Tan, Elizabeth de Oliveira, Collins Karikari, Maria C. Villaroel, Ana Lúcia Ribeiro Salomón, Gretchen Taylor, Rajni Sharma, Ralph H. Hruban, Anirban Maitra, Daniel A. Laheru, Belén Rubio‐Viqueira, Antonio Jimeno, Manuel Hidalgo   +15 more
openalex   +1 more source

Prolonged Prophylactic Antibiotics Based on Preoperative Bile Culture Reduce Surgical Site Infections After Pancreaticoduodenectomy Following Preoperative Biliary Drainage: A Propensity‐Matched Analysis

Annals of Gastroenterological Surgery, Volume 10, Issue 1, Page 197-210, January 2026.
ABSTRACT Objective The optimum duration of prophylactic antibiotics after pancreaticoduodenectomy following preoperative biliary drainage to prevent surgical site infections remains controversial. We evaluate whether a prolonged course of prophylactic antibiotics reduces surgical site infection after pancreaticoduodenectomy following biliary drainage ...
Kyohei Matsumoto, Atsushi Shimizu, Yuji Kitahata, Akihiro Takeuchi, Hideki Motobayashi, Masatoshi Sato, Tomohiro Yoshimura, Shinya Hayami, Atsushi Miyamoto, Manabu Kawai   +9 more
wiley   +1 more source

Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer

, 2020
Ryota Takahashi, Hideaki Ijichi, Makoto Sano, Koji Miyabayashi, Dai Mohri, Jin-Suk Kim, Gen Kimura, T. Nakatsuka, Hiroaki Fujiwara, Keisuke Yamamoto, Yotaro Kudo, Yasuo Tanaka, Keisuke Tateishi, Yousuke Nakai, Yasuyuki Morishita, Katsura Soma, Norihiko Takeda, Harold L. Moses, Hiroyuki Isayama, Kazuhiko Koike   +19 more
openalex   +1 more source

Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells [PDF]

, 2016
Vivien Koh, Hsueh Yin Kwan, Woei Loon Tan, Tzia Liang Mah, Wei Peng Yong   +4 more
openalex   +1 more source