Results 101 to 110 of about 1,154,991 (281)

Tests for Gene-Environment Interactions and Joint Effects with Exposure Misclassification [PDF]

, 2015
The number of methods for genome-wide testing of gene-environment interactions (GEI) continues to increase with the hope of discovering new genetic risk factors and obtaining insight into the disease-gene-environment relationship.
Ahn, Jaeil, Boonstra, Philip S, Chatterjee, Nilanjan, Gruber, Stephen B, Mukherjee, Bhramar, Schmit, Stephanie L   +5 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Expanding the modern synthesis II: Formal perspectives on the inherent role of niche construction in fitness [PDF]

, 2010
Expanding the modern synthesis requires elevating the role of interaction within and across various biological scales to the status of an evolutionary principle.
Rodrick Wallace
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Characteristics of the phenotypes in prevalent and incident cases of heart failure in primary care: IBERICAN study

BMC Primary Care
Background The management in primary care (PC) of the patients with Heart Failure (HF) is different from the management hospital, in a special way compared to cardiology departments.
Sergio Cinza-Sanjurjo, Miguel Ángel Prieto-Díaz, Vicente Pallarés-Carratalá, Rafael M. Micó-Pérez, Sonsoles Velilla-Zancada, Alfonso Barquilla-García, Leovigildo Ginel-Mendoza, Antonio Segura-Fragoso, Vicente Martín-Sánchez, José Polo-García   +9 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Interaction between Risk Single-Nucleotide Polymorphisms of Developmental Dyslexia and Parental Education on Reading Ability: Evidence for Differential Susceptibility Theory

Behavioral Sciences
While genetic and environmental factors have been shown as predictors of children’s reading ability, the interaction effects of identified genetic risk susceptibility and the specified environment for reading ability have rarely been investigated.
Qing Yang, Chen Cheng, Zhengjun Wang, Ximiao Zhang, Jingjing Zhao   +4 more
doaj   +1 more source

Supplementary Figure 1 from A Model of Gene-Environment Interaction Reveals Altered Mammary Gland Gene Expression and Increased Tumor Growth following Social Isolation [PDF]

, 2023
James B. Williams, Diana Pang, Bertha Delgado, Masha Kocherginsky, Maria Tretiakova, Thomas Krausz, Deng Pan, Jane He, Martha K. McClintock, Suzanne D. Conzen   +9 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Introduction to the Special Issue: The Interplay Between Genetic Factors and the Peer Environment in Explaining Children\u27s Social Adjustment [PDF]

, 2014
Virtually all aspects of human development are subject to both genetic (i.e., heritable) and environmental influences that conjointly shape developmental outcomes through various mechanisms of gene–environment interplay.
Brendgen, Mara
core   +1 more source