Results 101 to 110 of about 1,143,176 (286)

Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy

Environment International, 2019
Background: Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications ...
Shangzhi Gao, Md. Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Mohammad Rahman, Li Su, Yu-mei Hsueh, Marc Weisskopf, Brent Coull, David C. Christiani   +9 more
doaj   +1 more source

Expanding the modern synthesis II: Formal perspectives on the inherent role of niche construction in fitness [PDF]

, 2010
Expanding the modern synthesis requires elevating the role of interaction within and across various biological scales to the status of an evolutionary principle.
Rodrick Wallace
core   +1 more source

High-throughput allele-specific expression across 250 environmental conditions [PDF]

, 2016
Gene-by-environment (GxE) interactions determine common disease risk factors and biomedically relevant complex traits. However, quantifying how the environment modulates genetic effects on human quantitative phenotypes presents unique challenges ...
Alazizi, Adnan, Davis, Gordon O, Harvey, Chris T, Hauff, Nancy J., Kalita, Cynthia A, Kurtz, Daniel, Luca, Francesca, Moyerbrailean, Gregory A, Pique-Regi, Roger, Richards, Allison L, Sorokin, Yoram, Watza, Donovan, Wen, Xiaoquan, Zhou, Xiang   +13 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers

Toxics
Benzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual and combined effects on genetic damage at low exposure levels are not fully understood.
Shuangqi Li, Xiaojing Liao, Rui Ma, Na Deng, Haimei Wu, Zhaorui Zhang, Liping Chen, Qing Wang, Qilong Liao, Qianxi Li, Xinyi Ouyang, Yongmei Xiao, Qifei Deng   +12 more
doaj   +1 more source

Cross-cultural comparison of genetic and cultural transmission of smoking initiation using an extended twin kinship model [PDF]

, 2018
Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior.
Eaves, Lindon J, Heath, Andrew C, Kendler, Kenneth S, Maes, Hermine H, Martin, Nicholas G, Morley, Kate, Neale, Michael C   +6 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Molecular Pathways Linking High-Fat Diet and PM_2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis

Biomolecules
Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions. This systematic review and meta-analysis examined the molecular mechanisms underlying metabolically abnormal obesity caused by exposure to a high-fat diet (HFD ...
Sagrario Lobato, Víctor Manuel Salomón-Soto, Claudia Magaly Espinosa-Méndez, María Nancy Herrera-Moreno, Beatriz García-Solano, Ernestina Pérez-González, Facundo Comba-Marcó-del-Pont, Mireya Montesano-Villamil, Marco Antonio Mora-Ramírez, Claudia Mancilla-Simbro, Ramiro Álvarez-Valenzuela   +10 more
doaj   +1 more source

Introduction to the Special Issue: The Interplay Between Genetic Factors and the Peer Environment in Explaining Children\u27s Social Adjustment [PDF]

, 2014
Virtually all aspects of human development are subject to both genetic (i.e., heritable) and environmental influences that conjointly shape developmental outcomes through various mechanisms of gene–environment interplay.
Brendgen, Mara
core   +1 more source

Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study [PDF]

, 2014
Background: Given the relationship between iron metabolism and lead toxicokinetics, we hypothesized that polymorphisms in iron metabolism genes might modify maternal-fetal lead transfer.
Bellinger, David C, Ettinger, Adrienne S, Hatley, Earl L, Hu, Howard, Jim, Rebecca, Just, Allan C, Karwowski, Mateusz P, Wright, Robert O   +7 more
core   +1 more source