Results 81 to 90 of about 12,471,578 (252)

The Impact of Gene–Environment Interaction on Alcohol Use Disorders

Alcohol Research, 2012
This article describes three types of gene–environment interactions and the challenges inherent in interpreting these interactions. It also reports on what is known about gene–environment interactions in the field of alcohol use disorders ...
Danielle M. Dick, Kenneth S. Kendler
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence [PDF]

, 2017
There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure.
Consortium, for the Ovarian Cancer Association, Kiemeney, Lambertus, Joellen M Schildkraut, Susanne K Kjaer, Jonathan P Tyrer, Rossing, Mary Anne, Ness, Roberta B, Argyrios Ziogas, Anton-Culver, Hoda, Elisa V Bandera, Simon A Gayther, Mukherjee, Bhramar, Celeste Leigh Pearce, Schildkraut, Joellen M, Kirsten B Moysich, Pearce, Celeste Leigh, Cramer, Daniel W, Seunggeun Lee, Alice W Lee, Francesmary Modugno, Lee, Alice W, Bandera, Elisa V, Moysich, Kirsten B, Gentry-Maharaj, Aleksandra, Gang Liu, Tyrer, Jonathan P, Pharoah, Paul D, Brooke L Fridley, Usha Menon, Fridley, Brooke L, null null, Modugno, Francesmary, Ramus, Susan J, Lambertus Kiemeney, Roberta B Ness, Wu, Anna H, Jenny Chang-Claude, Leon Massuger, Menon, Usha, Jensen, Allan, Lee, Seunggeun, Liu, Gang, Paul D Pharoah, Harvey Risch, Daniel W Cramer, Kjaer, Susanne K, Kathryn L Terry, Risch, Harvey, Anna H Wu, Chang-Claude, Jenny, Penelope M Webb, Jennifer A Doherty, Ziogas, Argyrios, Bhramar Mukherjee, Mary Anne Rossing, Webb, Penelope M, Aleksandra Gentry-Maharaj, Susan J Ramus, Hoda Anton-Culver, Massuger, Leon, Allan Jensen, Terry, Kathryn L, Gayther, Simon A, Goode, Ellen L, Ellen L Goode, Andrew Berchuck, Berchuck, Andrew, Doherty, Jennifer A, Wu, A.H., Pearce, C.L., Lee, Alice W., Massuger, L.F., Risch, H., Kiemeney, L.A., Bandera, E.V.   +74 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Gene-Environment interaction of genetic variants with alcohol and smoking in CP.

, 2016
Gene-Environment interaction of genetic variants with alcohol and smoking in CP.
Kshaunish Das (2183604), Priyanka Banerjee (485749), Pramod K. Garg (2183622), Syed Jafar Mehdi (2183618), Ankita Agrawal (2183614), Anil K. Giri (2183608), Surinder Rana (2183626), Shallu Midha (2183606), Ritika Lakhotia (2183620), Samir Mohindra (2183602), Deepak K. Bhasin (2183610), Rajan Dhingra (2183616), Ismeet Kaur (2183612), Saurabh Ghosh (1234137), Dwaipayan Bharadwaj (126561), Ramesh Kumar G. (2183624)   +15 more
core   +1 more source

Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome [PDF]

, 2009
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory ...
Wichmann, Heinz-Erich, Holzapfel, C., Singmann, Paula, Grallert, Harald, Singmann, P., Wichmann, H.-E., Holzapfel, Christina, Illig, T., Klingenspor, Martin, Klingenspor, M., Grallert, H., Herder, C., Illig, Thomas, Rathmann, Wolfgang, Baumert, Jens, Meisinger, Christa, Rathmann, W., Baumert, J.J., Klopp, Norman, Klopp, N., Herder, Christian, Meisinger, C., Singmann, Paula;Baumert, Jens;Herder, Christian;Meisinger, Christa;Holzapfel, Christina;Klopp, Norman;Wichmann, H.-Erich;Klingenspor, Martin;Rathmann, Wolfgang;Illig, Thomas;Grallert, Harald, Singmann, P., Baumert, J., Herder, C., Meisinger, C., Holzapfel, C., Klopp, N., Wichmann, H.-E., Klingenspor, M., Rathmann, W., Illig, T., Grallert, H.   +23 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

A Nonlinear Model for Gene-Based Gene-Environment Interaction

, 2016
A vast amount of literature has confirmed the role of gene-environment (G×E) interaction in the etiology of complex human diseases. Traditional methods are predominantly focused on the analysis of interaction between a single nucleotide polymorphism (SNP)
Jian Sa, Yuehua Cui, Tao He, Xu Liu, Guifen Liu   +4 more
core   +1 more source