Results 81 to 90 of about 11,702,336 (253)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Gene-gene and gene-environment interactions in meta-analysis of genetic association studies. [PDF]

, 2015
Extensive genetic studies have identified a large number of causal genetic variations in many human phenotypes; however, these could not completely explain heritability in complex diseases.
Sui-Lung Su, Lin, John, Hsin-Yi Yang, Chi-Ming Chu, Sui-Lung Su (306303), Chu, Chi-Ming, Chin Lin (28524), Su, Sui-Lung, John Lin (273102), Yang, Hsin-Yi, Chin Lin, John Lin, Chi-Ming Chu (306302), Lin, Chin, Hsin-Yi Yang (398581)   +14 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

GIS mapping and gene-environment interaction

, 2014
Gene-environment interaction and GIS mapping were two major methods for spatial data analysis in public health sector. In the past, researchers often used the gene-environment interaction method to study the relationship between the environmental ...
Zhu, Jialing
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gene-gene interaction network.

The identified miR target genes were analysed by means of a gene-gene interaction network using functional protein association networks software (String and Cytoscape software). The nodes in the networks are sized by their node degree. (TIF)
Marzia Rossato (3424763), Cristina Beltrami (2634700), Marco Tomasetti (293754), Federica Monaco (826196), Lory Santarelli (293775), Monica Amati (353759), Giacomo Sollini (17781413), Ernesto Pasquini (5754995), Massimo Re (5754986), Gaia Goteri (590527), Corrado Rubini (10527), Concetta De Quattro (17781410)   +11 more
core   +1 more source

Gene-Environment interaction in tobacco-related cancers

, 2008
This review summarizes the carcinogenic effects of tobacco smoke and the basis for interaction between tobacco smoke and genetic factors. Examples of published papers on gene tobacco interaction and cancer risk are presented.
Emanuela Taioli, Md Phd, Taioli Md, E. Taioli, Address Emanuela   +4 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source