Results 61 to 70 of about 12,471,578 (252)

Suggested interpretation of quantile-dependent penetrance and gene-environment interaction.

, 2013
Suggested interpretation of quantile-dependent penetrance and gene-environment interaction.
Paul T. Williams (251599)
core   +1 more source

Gene-gene and gene-environment interactions of CYP19A1, ESR1, IL6, IL6R, IL1β, RANK, and RANKL variants in relation to osteoporosis and hip fracture risk in Mexican women

Frontiers in Aging
BackgroundOsteoporosis is a complex disease influenced by genetic variants, environmental factors, and comorbidities. While individual single-nucleotide variants (SNVs) have been associated with disease risk, limited data are available on how gene–gene ...
Antonio Miranda-Duarte, Valeria Ponce de León-Suárez, Alberto Hidalgo-Bravo, Rafael Velázquez-Cruz, Esperanza Ramírez-Pérez, O. Celeste Martínez-Ramírez, Clementina Castro-Hernández, Blanca Barredo-Prieto, Leonora Casas-Avila   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Gene-Environment interaction in tobacco-related cancers

, 2008
This review summarizes the carcinogenic effects of tobacco smoke and the basis for interaction between tobacco smoke and genetic factors. Examples of published papers on gene tobacco interaction and cancer risk are presented.
Emanuela Taioli, Md Phd, Taioli Md, E. Taioli, Address Emanuela   +4 more
core   +1 more source

Gene-gene and gene-environment interactions in meta-analysis of genetic association studies. [PDF]

, 2015
Extensive genetic studies have identified a large number of causal genetic variations in many human phenotypes; however, these could not completely explain heritability in complex diseases.
Sui-Lung Su, Lin, John, Hsin-Yi Yang, Chi-Ming Chu, Sui-Lung Su (306303), Chu, Chi-Ming, Chin Lin (28524), Su, Sui-Lung, John Lin (273102), Yang, Hsin-Yi, Chin Lin, John Lin, Chi-Ming Chu (306302), Lin, Chin, Hsin-Yi Yang (398581), Lin Chin, Chu Chi-Ming, Su Sui-Lung, Yang Hsin-Yi, Lin John   +19 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Epigenetic metaphors: an interdisciplinary translation of encoding and decoding

New Genetics and Society, 2019
Looking at the new and often disputed science of epigenetics, we examined the challenges faced by scientists when they communicate scientific research to the public. We focused on the use of metaphors to illustrate notions of epigenetics and genetics. We
Aviad Raz, Gaëlle Pontarotti, Jonathan B. Weitzman   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk

Annals of Medicine
Background Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart
Jianhui Wei, Peng Huang, Letao Chen, Tubao Yang, Tingting Wang, Ziye Li, Lizhang Chen, Jiabi Qin   +7 more
doaj   +1 more source

Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy

Environment International, 2019
Background: Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications ...
Shangzhi Gao, Md. Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Mohammad Rahman, Li Su, Yu-mei Hsueh, Marc Weisskopf, Brent Coull, David C. Christiani   +9 more
doaj   +1 more source