Results 61 to 70 of about 1,163,174 (254)
Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy
Environment International, 2019 Background: Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications ...
Shangzhi Gao +9 more
doaj +1 more source
Genotype by environment interaction for gene expression in Drosophila melanogaster
Nature Communications, 2020 Huang et al. show that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co-expression network remains robust.
Wen Huang +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. [PDF]
, 2015 Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD).
Boss, JM +11 more
core +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Epigenetic Landscape of Interacting Cells: A Model Simulation for Developmental Process
, 2010 We propose a physical model for developmental process at cellular level to discuss the mechanism of epigenetic landscape. In our simplified model, a minimal model, the network of the interaction among cells generates the landscape epigenetically and the ...
Bar-Even +19 more
core +1 more source
2D association and integrative omics analysis in rice provides systems biology view in trait analysis. [PDF]
, 2018 The interactions among genes and between genes and environment contribute significantly to the phenotypic variation of complex traits and may be possible explanations for missing heritability.
Dai, Xinbin +3 more
core +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Epigenetic metaphors: an interdisciplinary translation of encoding and decoding
New Genetics and Society, 2019 Looking at the new and often disputed science of epigenetics, we examined the challenges faced by scientists when they communicate scientific research to the public. We focused on the use of metaphors to illustrate notions of epigenetics and genetics. We
Aviad Raz +2 more
doaj +1 more source
Random regression models for detection of gene by environment interaction
Genetics Selection Evolution, 2007 Two random regression models, where the effect of a putative QTL was regressed on an environmental gradient, are described. The first model estimates the correlation between intercept and slope of the random regression, while the other model restricts ...
Meuwissen Theo HE +2 more
doaj +1 more source