Results 51 to 60 of about 11,702,336 (253)

Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome [PDF]

, 2009
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory ...
Wichmann, Heinz-Erich, Holzapfel, C., Singmann, Paula, Grallert, Harald, Singmann, P., Wichmann, H.-E., Holzapfel, Christina, Illig, T., Klingenspor, Martin, Klingenspor, M., Grallert, H., Herder, C., Illig, Thomas, Rathmann, Wolfgang, Baumert, Jens, Meisinger, Christa, Rathmann, W., Baumert, J.J., Klopp, Norman, Klopp, N., Herder, Christian, Meisinger, C., Singmann, Paula;Baumert, Jens;Herder, Christian;Meisinger, Christa;Holzapfel, Christina;Klopp, Norman;Wichmann, H.-Erich;Klingenspor, Martin;Rathmann, Wolfgang;Illig, Thomas;Grallert, Harald, Singmann, P., Baumert, J., Herder, C., Meisinger, C., Holzapfel, C., Klopp, N., Wichmann, H.-E., Klingenspor, M., Rathmann, W., Illig, T., Grallert, H.   +23 more
core   +1 more source

Genotype by environment interaction for gene expression in Drosophila melanogaster

Nature Communications, 2020
Huang et al. show that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co-expression network remains robust.
Wen Huang, Mary Anna Carbone, Richard F. Lyman, Robert R. H. Anholt, Trudy F. C. Mackay   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function [PDF]

, 2012
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC).
Wenbo Tang (110161), Alisa K. Manning (110227), Heinrich, J (Joachim), Thomas Lumley (57337), Sood, A, R Graham Barr, Brusselle, Guy G., Loth, Daan W, Akshay Sood (71826), O'Connor, George T, Liu, YM, Stephen S. Rich (7634141), Harris, Tamara B, Fornage, Myriam, Alisa K. Manning (7634102), Stephanie J. London (62450), Josée Dupuis (28859), Probst-Hensch, Nicole, Glaser, S., Chen, TH, Elliott, Paul, Eiriksdottir, Gudny, Zhai, G., Jason Z. Liu (7634093), Patricia A. Cassano (110298), Hugues Aschard (110171), Joachim Heinrich (60421), Guy G Brusselle, Couper, D. J., Gu, Xiangjun, Uitterlinden, Andre G., Smith, AV, Couper, DJ, Lenore J. Launer (110269), Matthias Wjst (56613), Myriam Fornage (45591), Kritchevsky, S. B., Postma, Dirkje S., Liu, Y, Mirel, D. B., Rurth J.F. Loos (7634099), H. Marike Boezen (7634168), Uitterlinden, André G, Hysi, Pirro G., R. Graham Barr (7634171), Timothy D. Spector (7634159), Glaeser, S, Loos, Ruth J F, Christer Janson, Burkart, Kristin Marie, Barr, R.G., Heinrich, Joachim, Eiriksdottir, G, Hysi, P., Boezen, H Marike, Zhai, GJ, Liu, Jason, Probst-Hensch, Nicole M, Hancock, D.B., O Dale Williams, George T. O'Connor (110263), Jason Z. Liu (110210), Uitterlinden, AG, Hofman, A., Heckbert, Susan R, David P Strachan, Daan W. Loth (7634072), Louise V. Wain (7588511), Tamara B Harris, Smith, Albert V, Jarvis, Deborah, Imboden, M., Launer, Lenore J, Heckbert, Susan R., Hysi, PG, Morrison, A. C., Marciante, K. D., Rich, Stephen S., Hartikainen, Anna-Liisa, Mirel, Daniel B, Harris, Tamara, Liu, Jason Z, Jarvelin, Marjo-Riitta, Kritchevsky, S.B., Kari E. North (68131), Aldrich, Melinda C., Manning, A. K., Koch, B., Couper, David J., Timothy D Spector, Curjuric, I., Wilk, J. B., Eijgelsheim, Mark, North, Kari E, Louise V Wain, Rivadeneira, F, Williams, O. D., Homuth, G, Marciante, KD, Cassano, P. A., Joanna Smolonska (101730), Susan R. Heckbert (7634165), Strachan, David P., Jarvelin, M.R., Henry Völzke (64286), Boezen, H. M., Marciante, Kristin D., Vonk, J.M., Jerome I. Rotter (7634114), Ramasamy, A, Alisa K Manning, Loehr, L.R., Lumley, T., Amanda Henry, Daniel B. Mirel (7634153), Mark Eijgelsheim (110185), Bernd Meibohm (110267), Manichaikul, A, Manichaikul, Ani, Amy R Bentley, Daan W Loth, Kristin D. Marciante (110230), Aldrich, Melinda, Zhao, Jing Hua, Hysi, Pirro, Kurt Lohman, Alanna C Morrison, Melinda C. Aldrich (110234), Meibohm, B, O'Connor, George, Imboden, Medea, Gharib, Sina A, Wilk, Jemma B., Gudny Eiriksdottir (8872), Obeidat, Ma’en, Marchini, J, Stricker, Bruno H. C., Laurie, C.C., Kurt Lohman (110218), O. Dale Williams (110242), Stephen B. Kritchevsky (7240181), Alanna C. Morrison (110248), Lenore J Launer, Franceschini, N, Tamara B. Harris (7240184), Launer, L.J., O’Connor, George T., Probst-Hensch, NM, Maria Soler Artigas (7634069), Launer, Lenore J., Marchini, Jonathan, Dupuis, Josee, Hall, Ian, Tobin, M.D., Loehr, Laura, Nicole M. Probst-Hensch (7634162), London, S.J., Fernando Rivadeneira, Rich, S. S., Sina A. Gharib (63265), Cathy C. Laurie (110245), Kristin D. Marciante (7634105), Hancock, D. B., Stricker, BHC, Wareham, N.J., Tamara B. Harris (110195), Henry, A, Guangju Zhai (110167), Bonnie R. Joubert (110252), Ian P. Hall (7377620), Probst-Hensch, Nicole M., Rotter, Jerome I, Nicholas J Wareham, Vonk, Judith, Dana B. Hancock (110121), R. Graham Barr (109958), Franceschini, Nora, Hammond, Christopher J., Burkart, KM, Bruno H C Stricker, Rochat, Thierry, Rotter, Jerome, Tobin, Martin, Hall, I.P., Boezen, H. Marike, Loos, Ruth J. F., Artigas, M.S., Loth, Daan W., Josée Dupuis, Medea Imboden, Lohman, K, Hall, I. P., Deborah Jarvis, Wain, Louise V., Guy G. Brusselle (7634108), Burkart, K.M., André G. Uitterlinden (7634138), North, K.E., Loos, RJF, Judith M. Vonk (7634135), George T O'Connor, McArdle, Wendy L., Laurie, Cathy C., Barr, R. Graham, Dupuis, J, Khaw, K. T., Koch, B, Hancock, Dana, Burkart, Kristin, Manning, Alisa K., Tobin, Martin D, Jemma B Wilk, Völzke, H, Paul Elliott, Rochat, T., Artigas, Maria Soler, Probst-Hensch, N.M., Boezen, Hendrika, Homuth, G., Patricia A. Cassano (7634174), Stephanie J. London (7634180), Melinda C Aldrich, Gudnason, V, Albert V. Smith (7634078), Bentley, Amy, Pirro G. Hysi (110207), Smith, Albert, Gharib, SA, Rich, Stephen, Williams, O.D., Albert V Smith, Martin D Tobin, Marjo-Riitta Jarvelin (110290), Dana B. Hancock (7634066), Wareham, N. J., Guy G. Brusselle (110236), Wareham, NJ, Bruce M Psaty, Ani Manichaikul, Smith, Albert V., Anna-Liisa Hartikainen, Nicole M Probst-Hensch, Chen, T-H, Sood, A., Ruth J F Loos, Bentley, Amy R, Gu, X, Jarvelin, MR, Adaikalavan Ramasamy, Daniel B Mirel, Uitterlinden, A., Jing Hua Zhao, Bruno H. C. Stricker (110279), Burkart, Kristen M., Morrison, Alanna, Rotter, J.I., Hall, IP, Psaty, B. M., Meibohm, Bernd, Couper, David, Homuth, Georg, Harris, TB, Heckbert, S. R., Laurie, CC, Chen, T. H., Kritchevsky, Stephen, Mirel, Daniel B., Christopher J Hammond, Akshay Sood, Xiangjun Gu, Daan W. Loth (110140), Wareham, Nicholas J., Obeidat, M, Smolonska, J, Marciante, Kristin, Gharib, S.A., Laurie, C., Psaty, Bruce, Lumley, Thomas, Sven Gläser, André G. Uitterlinden (2213413), Hofman, Albert, Zhao, J.H., Zhao, JH, Jerome I. Rotter (103729), Loehr, Laura R, Yongmei Liu, Myriam Fornage, Cassano, Patricia A, Hartikainen, A. L., Xiangjun Gu (73651), Stricker, Bruno HC, Zhao, J. H., Gu, X.J., Volzke, H., Tang, W, Brusselle, GG, Bentley, A.R., Tang, Wenbo, Voelzke, Henry, Stephen B Kritchevsky, Boezen, Marike, Dana B Hancock, Laurie, Cathy C, London, S. J., Vilmundur Gudnason (8873), Brusselle, G.G., Strachan, DP, Jonathan Marchini (21497), Patricia A Cassano, Elliott, P., Susan R. Heckbert (110293), Wjst, M, Martin D. Tobin (110311), Wareham, Nicholas, North, KE, Spector, TD, David J Couper, Chen, Ting-hsu, Rotter, JI, Ramasamy, A., Nicholas J. Wareham (110277), Aldrich, M.C., Wain, Louise, Marjo-Riitta Jarvelin, Spector, Timothy D, Ma'en Obeidat, Manning, A.K., Psaty, Bruce M., Launer, Lenore, Lohman, Kurt, Adaikalavan Ramasamy (4841), Ma'en Obeidat (110232), Hartikainen, A.L., Peter Kraft, Gudnason, V., Dirkje S Postma, Strachan, D. P., Henry Völzke, Tobin, MD, Loehr, L. R., Morrison, Alanna C, Wain, LV, Thierry Rochat, Mcardle, Wendy, Smolonska, Joanna, Stricker, Bruno, Dirkje S. Postma (101740), Manning, AK, Barr, RG, Boezen, M., Kraft, Phillip, Vonk, JM, Loth, D.W., Henry, A., Soler, Artigas, Bentley, A. R., Obeidat, Ma'en, Hysi, P.G., Launer, L. J., Timothy D. Spector (110281), Strachan, David P, Brusselle, Guy, Christopher J. Hammond (110274), Liu, JZ, Loth, D. W., Vonk, Judith M., Wendy L. McArdle (110155), Bernd Meibohm, Loehr, LR, Hammond, Christopher J, Spector, T. D., Marchini, J., Cisca Wijmenga, Vonk, Judith M, Ting-hsu Chen, Ting-Hsu Chen (7634111), Barr, R Graham, Ruth J. F. Loos (110224), Hofman, Bert, Brusselle, G. G., North, Kari, Aschard, H., Zhai, G.J., Kraft, P., Stephen B. Kritchevsky (110259), Bonnie R Joubert, David J. Couper (110257), O'Connor, G. T., O'Connor, G.T., Heinrich, J., Ting-hsu Chen (110239), Judith M Vonk, Ramasamy, Adaikalavan, Psaty, Bruce M, Sven Gläser (110276), Nicholas J. Wareham (7584569), Wain, L. V., Boezen, M, Aldrich, MC, Hancock, DB, Heckbert, SR, Hammond, C. J., H Marike Boezen, Christopher J. Hammond (7252211), North, Kari E., Zhai, G, Jing Hua Zhao (73808), Lumley, T, Aldrich, M., Smolonska, J., Vonk, J. M., Mirel, D.B., Khaw, KT, Hartikainen, AL, Lenore J. Launer (7305602), Beate Koch (110151), Stricker, B. H. C., Smith, A.V., Heckbert, Susan, Kay-Tee Khaw, Williams, O. Dale, Uitterlinden, André, Hancock, Dana B., Ian P. Hall (110307), Kraft, P, Khaw, K-T, Kritchevsky, SB, Nora Franceschini, Jemma B. Wilk (110164), Wareham, Nicholas J, Georg Homuth (110202), Tobin, M. D., Curjuric, Ivan, Amy R. Bentley (110243), Joubert, B. R., Rochat, T, Gharib, Sina, Franceschini, N., Vilmundur Gudnason, Mirel, Daniel, Marciante, K.D., Guangju Zhai, Janson, Christer,, Artigas, MS, Laura R. Loehr (110214), Rivadeneira, Fernando, Rich, SS, Melinda C. Aldrich (6688181), Boezen, HM, Albert V. Smith (103644), Manning, Alisa K, Morrison, Alanna C., Janson, C, Wijmenga, C, Jarvelin, M-R, Bentley, AR, Obeidat, M., David J. Couper (7634132), Harris, T.B., Mark Eijgelsheim, Kristin M. Burkart (110174), Bentley, Amy R., Jing Hua Zhao (7634084), Kristin M. Burkart (7634087), Loth, DW, Jonathan Marchini, London, SJ, Judith M. Vonk (71591), Kristin D Marciante, Spector, Timothy, Rivandeneiro, Fernando, Ani Manichaikul (110134), Rotter, J. I., Liu, Y.M., Völzke, Henry, Aschard, Hugues, O'Connor, GT, Heinrich, J, Martin D. Tobin (7581161), Fornage, M., Barr, R. G., Bruce M. Psaty (103721), Gu, XJ, Zhai, Guangju, Jarvelin, M. R., Marciante, Kristin D, Ivan Curjuric (110179), Eiriksdottir, G., Susan R Heckbert, Sina A Gharib, Spector, Timothy D., Gläser, Sven, Homuyth, Georg, Medea Imboden (110145), Thomas Lumley, Hysi, Pirro G, Probst-Hensch, N. M., Gu, X., Harris, Tamara B., London, Stephanie J, Henry, Amanda, Liu, J.Z., Joubert, BR, Peter Kraft (15118), Bruce M. Psaty (7634144), Bruno H.C. Stricker (7634156), Jerome I Rotter, Heckbert, S.R., Strachan, David, Wjst, M., Cathy C. Laurie (7634123), Meibohm, B., Strachan, D.P., Launer, LJ (Lenore), Gudnason, Vilmundur, Hugues Aschard, Loehr, Laura R., Jarvis, D, Rich, S.S., Uitterlinden, André; id_orcid, Loth, Daan, Mirel, DB, Khaw, Kay-Tee, Postma, Dirkje S, Wain, L.V., Hall, Ian P, Rivadeneira, F., Deborah Jarvis (59834), Liu, Yongmei, Nicole M. Probst-Hensch (110284), Wilk, JB, Khaw, K.T., Ivan Curjuric, Karl E. North (7634150), Postma, D.S., Curjuric, I, Liu, Jason Z., Kristin M Burkart, David P. Strachan (7634177), McArdle, W.L., Burkart, Kristin M, Soler Artigas, María, Joanna Smolonska, Williams, O Dale, Kraft, Peter, Gläser, S, Pirro G. Hysi (7634090), Liu, J. Z., Eijgelsheim, M., Morrison, AC, Smith, A. V., Kay-Tee Khaw (110271), Wijmenga, Cisca, Albert Hofman, Elliott, P, Wendy L. McArdle (7634075), London, Stephanie J., Fornage, M, Hammond, C.J., Gharib, Sina A., André G Uitterlinden, Voelzke, H, Loos, R., María Soler Artigas (110124), Hammond, CJ, Postma, Dirkje, Joubert, Bonnie, O'Connor, George T., Laurie, Cathy, Stricker, B.H.C., Joubert, B.R., Chen, T.H., McArdle, Wendy L, Kritchevsky, Stephen B, Glaeser, Sven, Loos, RJ, Alanna C. Morrison (7634126), Aldrich, Melinda C, Brusselle, Guy G, Tang, W.B., Cassano, P.A., Uitterlinden, A.G., Cisca Wijmenga (32954), Joubert, Bonnie R., Imboden, M, Jemma B. Wilk (7634081), Jarvis, D., Rich, Stephen S, Ian P Hall, Christer Janson (83414), Sood, Akshay, Morrison, A.C., McArdle, WL, Harris, T. B., Hammond, Christopher, Amanda Henry (110129), Kari E North, Couper, David J, Psaty, BM, Wenbo Tang, London, Stephanie, McArdle, W., Cathy C Laurie, Hartikainen, A-L, Louise V. Wain (110260), Wjst, Matthias, Hancock, Dana B, Bonnie R. Joubert (7634129), Janson, C., Koch, Beate, David P. Strachan (110302), Loos, Ruth, Wijmenga, C., Cassano, PA, Pirro G Hysi, Joubert, Bonnie R, Stricker, Bruno H C, Stephanie J London, Eijgelsheim, M, Georg Homuth, H. Marike Boezen (101746), Dupuis, J., Manning, Alisa, Tang, W., Kritchevsky, Stephen B., Spector, T.D., Loos, R.J.F., George T. O'Connor (7634147), Manichaikul, A., Laura R Loehr, Amy R. Bentley (7634120), Psaty, B.M., Hofman, A, Postma, D., Stephen S. Rich (110262), Albert Hofman (107303), Wijmenga, Cisca; id_orcid, Matthias Wjst, Stricker, BH, Gharib, S. A., Wilk, Jemma, Burkart, Kristin M., Burkart, K. M., Beate Koch, Launer, LJ, O. Dale Williams (7634117), Cassano, Patricia A., Daniel B. Mirel (110265), Wilk, J.B., Joachim Heinrich, Tang, WB, Janson, Christer, Postma, DS, Stephen S Rich, North, K. E., Thierry Rochat (110261), Paul Elliott (27295), Laura R. Loehr (7634096), Hall, Ian P., Nora Franceschini (91434), Tobin, Martin D., Aschard, H, Wain, Louise V, Liu, Y., Couper, D.J., Rotter, Jerome I., Wendy L McArdle, Lohman, K., Gudny Eiriksdottir, Williams, OD, Jason Z Liu, Anna-Liisa Hartikainen (110272), Wilk, Jemma B, María Soler Artigas, Yongmei Liu (104713), Cassano, Patricia, Fernando Rivadeneira (61551), Loos, Ruth JF, London, S.J. (Stephanie), Rivadeneira Ramirez, F. (Fernando), Morrison, A.C. (Alanna), Heinrich, J. (Joachim), Bentley, A.R. (Amy), Cassano, P.A. (Patricia), Hall, I.P. (Ian), Smolonska, J. (Joanna), Rich, S.S. (Stephen), Harris, T.B. (Tamara), Khaw, K-T. (Kay-Tee), Tobin, M.D. (Martin), O'Connor, G.T. (George), Janson, C. (Christer), Franceschini, N. (Nora), Laurie, C.C. (Cathy), Loehr, L.R. (Laura), Homuth, G. (Georg), Völzke, H. (Henry), Hancock, D.B. (Dana), Gläser, S. (Sven), Loos, R.J.F. (Ruth), Wareham, N.J. (Nick), Joubert, B.R. (Bonnie), Imboden, M. (Medea), Gudnason, V. (Vilmundur), Gharib, S.A. (Sina), Williams, O.D. (Dale), Uitterlinden, A.G. (André), Sood, A. (Akshay), Manichaikul, A. (Ani), Burkart, K.M. (Kristin), Wain, L.V. (Louise), Hammond, C.J. (Christopher), Brusselle, G.G. (Guy), McArdle, W.L. (Wendy), Psaty, B.M. (Bruce), Vonk, J.M. (Judith), Curjuric, I. (Ivan), Smith, A.V. (Davey), Marchini, J. (Jonathan), Aschard, H. (Hugues), Strachan, D.P. (David), Manning, A.K. (Alisa), Jarvis, D.L. (Deborah), Boezen, H.M. (Marike), Marciante, K. (Kristin), Dupuis, J. (Josée), Wjst, M. (Matthias), Zhai, G. (Guangju), Liu, Y. (YongMei), Rotter, J.I. (Jerome), Probst-Hensch, N.M. (Nicole M.), Rochat, T. (Thierry), Koch, B. (Beate), Heckbert, S.R. (Susan), North, K.E. (Kari), Wijmenga, C. (Cisca), Elliott, P. (Paul), Aldrich, M.C. (Melinda), Loth, D.W. (Daan), Stricker, B.H.Ch. (Bruno), Eiriksdottir, G. (Gudny), Jarvelin, M.-R. (Marjo-Riitta), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Ramasamy, A. (Adaikalavan), Lohman, K. (Kurt), Mirel, D. (Daniel), Hysi, P.G. (Pirro), Spector, T.D. (Timothy), Henry, A. (Amanda), Hofman, A. (Albert), Kraft, P. (Peter), Zhao, J.H. (Jing Hua), Eijgelsheim, M. (Mark), Fornage, M. (Myriam), Liu, J. (Jason), Couper, D.J. (David), Gu, X. (Xiangjun), Lumley, T. (Thomas), Launer, L.J. (Lenore), Postma, D.S. (Dirkje), Barr, R.G. (Graham), Kritchevsky, S.B. (Stephen), Obeidat, M. (Ma'en), Meibohm, B. (Bernd)   +765 more
core   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Imputation of quantitative genetic interactions in epistatic MAPs by interaction propagation matrix completion [PDF]

, 2014
A popular large-scale gene interaction discovery platform is the Epistatic Miniarray Profile (E-MAP). E-MAPs benefit from quantitative output, which makes it possible to detect subtle interactions.
Zupan, Blaz, Zitnik, Marinka
core   +2 more sources

Gene by environment interaction in asthma

, 2006
Asthma is a chronic inflammatory disease of the airways that is highly prevalent in the Western world. It is a genetically complex disease caused by multiple genetic and environmental factors, which may interact.
Koppelman, Gerard H.; id_orcid
core   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models

Neurobiology of Disease, 2013
Interactions between genetic factors and environmental exposures are thought to be major contributors to the etiology of Parkinson's disease. While such interactions are poorly defined and incompletely understood, recent epidemiological studies have ...
Jason R. Cannon, J. Timothy Greenamyre
doaj   +1 more source