Results 41 to 50 of about 1,163,174 (254)

IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score

Frontiers in Genetics, 2022
Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang, Dongfang You, Honggang Yi, Sheng Yang, Yang Zhao, Yang Zhao, Yang Zhao   +6 more
doaj   +1 more source

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up [PDF]

, 2016
Rationale: The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent and may depend on genetic factors.
Antó, Josep M, Auffray, Charles, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Bousquet, Jean, Brauer, Michael, Brunekreef, Bert, Carlsten, Christopher, Chan-Yeung, Moira, Dep IRAS, dIRAS RA-2, Fuertes, Elaine, Gauderman, W James, Gref, Anna, Gruzieva, Olena, Heinrich, Joachim, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kebede Merid, Simon, Kere, Juha, Kobor, Michael S, Koppelman, Gerard H, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, LS IRAS EEPI ME (Milieu epidemiologie), MacIntyre, Elaina, Melén, Erik, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Pershagen, Göran, Postma, Dirkje, Risk Assessment, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian   +49 more
core   +3 more sources

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. [PDF]

, 2016
The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL).
Allayee, Hooman, Crow, Amanda L, Eskin, Eleazar, Friedman, Rick A, Ge, Marshall, Lavinsky, Joel, Lusis, Aldons J, Myint, Anthony, Pan, Calvin, Salehi, Pezhman, Wang, Juemei   +10 more
core   +3 more sources

Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction.

PLoS Genetics, 2016
How combinations of gene-environment interactions collectively give rise to genotype-environment interactions is not fully understood. To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two
Takeshi Matsui, Ian M Ehrenreich
doaj   +1 more source

Microbial Similarity between Students in a Common Dormitory Environment Reveals the Forensic Potential of Individual Microbial Signatures. [PDF]

, 2019
The microbiota of the built environment is an amalgamation of both human and environmental sources. While human sources have been examined within single-family households or in public environments, it is unclear what effect a large number of cohabitating
Gilbert, Jack A, Gottel, Neil, Lax, Simon, Richardson, Miles   +3 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Differential expression of placental glucocorticoid receptors and growth arrest-specific transcript 5 in term and preterm pregnancies: evidence for involvement of maternal stress. [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Pregnancy-specific stress predicts birth outcomes. We hypothesized that there is a maternal stress-GR interaction that can influence fetal birth weight.
Gidron, Y, Goumenou, A, Harvey, AJ, Karteris, E, Mparmpakas, D, Sotiriadis, G, Zachariades, E   +6 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Springer: An R package for bi-level variable selection of high-dimensional longitudinal data

Frontiers in Genetics, 2023
In high-dimensional data analysis, the bi-level (or the sparse group) variable selection can simultaneously conduct penalization on the group level and within groups, which has been developed for continuous, binary, and survival responses in the ...
Fei Zhou, Yuwen Liu, Jie Ren, Weiqun Wang, Cen Wu   +4 more
doaj   +1 more source