Results 31 to 40 of about 11,702,336 (253)

Candidate gene-environment interactions in substance abuse: A systematic review.

PLoS ONE, 2023
BackgroundThe abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders.
Zheng Jiang, Zidong Chen, Xi Chen
doaj   +1 more source

Dependent negative life events and sleep quality: An examination of gene-environment interplay. [PDF]

, 2011
Objectives: Negative life events are associated with sleep disturbances. Further understanding of these associations is beneficial as sleep disturbances are common.
Eley, Thalia C., Rijsdijk, Frühling, Thalia C. Eley, Gregory, Alice M., Nicola L. Barclay, Barclay, Nicola L., Rijsdijk, Fruhling V., Gregory, Alice, Fruhling V. Rijsdijk, Barclay, Nicola, Eley, Thalia, Alice M. Gregory   +11 more
core   +1 more source

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Gormand, A, Adriaens, M.E., Adriaens, Michiel E., Kolch, W, Amelie Gormand, Adriaens, ME, Gormand, A., Sturm, OE, David R Gilbert, Richard J Orton, Walter Kolch, Orton, RJ, Orton, Richard J., Oliver E Sturm, Gilbert, D, Gilbert, David R., Michiel Adriaens, M.E., Michiel E Adriaens, Orton, R.J., Kolch, Walter, Kolch, W., Gilbert, D.R., Sturm, O.E., Sturm, Oliver E., et al., Gormand, Amelie, Gormand, Amelie,, Lund University.   +27 more
core   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium

Breast Cancer Research, 2023
Background Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among ...
Kristin L. Young, Andrew F. Olshan, Kathryn Lunetta, Mariaelisa Graff, Lindsay A. Williams, Song Yao, Gary R. Zirpoli, Melissa Troester, Julie R. Palmer   +8 more
doaj   +1 more source

Replication of Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population [PDF]

Journal of Preventive Medicine and Public Health, 2016
Objectives Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity.
Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min   +2 more
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The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells

, 2009
Paternal exposure to genotoxic compounds is thought to contribute to diseases in their offspring. Therefore, it is of importance to develop biomarkers of male germ cell exposure to genotoxins.
Cemeli, E., Baumgartner, A., Anderson, D., van Delft, J., Godschalk, R.W., van Schooten, F.J., Linschooten, J.O.   +6 more
core   +1 more source

IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score

Frontiers in Genetics, 2022
Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang, Dongfang You, Honggang Yi, Sheng Yang, Yang Zhao, Yang Zhao, Yang Zhao   +6 more
doaj   +1 more source