Gene-environment interaction: A genetic-epidemiological approach [PDF]
Classical epidemiology addresses the distribution and determinants of diseases in populations, and the factors associated with disease causation, with the aim of preventing disease. Both genetic and environmental factors may contribute to susceptibility,
Pekmezović Tatjana
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A flexible Bayesian model for studying gene-environment interaction. [PDF]
An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence ...
Kai Yu +6 more
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Gene–Environment Interactions in Severe Mental Illness [PDF]
Severe mental illness (SMI) is a broad category that includes schizophrenia, bipolar disorder, and severe depression. Both genetic disposition and environmental exposures play important roles in the development of SMI. Multiple lines of evidence suggest that the roles of genetic and environmental factors depend on each other.
Rudolf eUher, Rudolf eUher
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Gene–Environment Interaction in Major Depression: Focus on Experience-Dependent Biological Systems [PDF]
Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple and partially overlapping sets of susceptibility genes interact each other and with the environment, predisposing individuals to the development of the illness. Thus, MDD results from a complex interplay of vulnerability genes and environmental factors that act ...
Nicola eLopizzo +8 more
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Mutual information for testing gene-environment interaction. [PDF]
Despite current enthusiasm for investigation of gene-gene interactions and gene-environment interactions, the essential issue of how to define and detect gene-environment interactions remains unresolved.
Xuesen Wu, Li Jin, Momiao Xiong
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Gene-environment interaction in psychopathologies: stress-related genetic and epigenetic influences [PDF]
It has long been known that stressful life events are related to various psychological problems. The relationship between stress and psychiatric disorders has been further recognized due to reports of studies investigating interactions between biological
Esra Zıvralı Yarar
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Gene-environment interaction in molar-incisor hypomineralization.
Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur
Mariana Bezamat +22 more
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How ambient temperature affects the heading date of foxtail millet (Setaria italica)
Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang +8 more
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Efficient gene–environment interaction testing through bootstrap aggregating
Gene–environment (GxE) interactions are an important and sophisticated component in the manifestation of complex phenotypes. Simple univariate tests lack statistical power due to the need for multiple testing adjustment and not incorporating potential ...
Michael Lau +3 more
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Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis
Background Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development.
Tian Xia, Kazuhiro Nakayama
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