Results 71 to 80 of about 12,471,578 (252)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Gene-Environment Interaction in Psychological Traits and Disorders

, 2011
There has been an explosion of interest in studying gene-environment interactions (GxE) as they relate to the development of psychopathology. In this article, I review different methodologies to study gene-environment interaction, providing an overview ...
Danielle M. Dick
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A case-only approach for assessing gene-sex interaction in human longevity [PDF]

As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected.
Karen Andersen-Ranberg, Bernard Jeune, Anatoli I. Yashin, Moniek De Maat, James W. Vaupel, Qihua Tan, Else M. Bladbjerg, Kaare Christensen   +7 more
core  

Effects of the family environment: Gene-environment interaction and passive gene-environment correlation

, 2008
The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children’s development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do
Thomas S. Price, Price, Thomas S., Thomas S. Price, Jaffee, Sara, Sara R. Jaffee   +4 more
core   +1 more source

GIS mapping and gene-environment interaction

, 2014
Gene-environment interaction and GIS mapping were two major methods for spatial data analysis in public health sector. In the past, researchers often used the gene-environment interaction method to study the relationship between the environmental ...
Zhu, Jialing
core   +1 more source

Oxytocin receptor gene (OXTR) and deviant peer affiliation: A gene-environment interaction in adolescent antisocial behavior [PDF]

, 2019
Although the oxytocin receptor gene (OXTR) is involved in aggression and social affiliation, it has not been examined in gene-environment interaction studies.
Iro Fragkaki, van Lier, Pol A.C., Branje, Susan J.T., Susan J. T. Branje, Koot, Hans M., Boks, Marco P., Leerstoel Branje, Dominique F. Maciejewski, Hans M. Koot, Verhagen, Maaike, Maaike Cima, Pol A. C. van Lier, Cima, Maaike, Meeus, Wim H.J., Maaike Verhagen, Branje, Susan J. T., Meeus, Wim H. J., Wim H. J. Meeus, Maciejewski, Dominique F., Van Lier, Pol A. C., Marco P. Boks, Fragkaki, Iro, Adolescent development: Characteristics and determinants, Brain, Maciejewski, D.F., Lier, P.A.C. van, Branje, S.J.T., Verhagen, M., Cima, M.J., Boks, M.P.M., Koot, J.M., Meeus, W.H.J., UMC Utrecht, Fragkaki, I., Onderzoeksgroep 2   +34 more
core   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Random regression models for detection of gene by environment interaction

Genetics Selection Evolution, 2007
Two random regression models, where the effect of a putative QTL was regressed on an environmental gradient, are described. The first model estimates the correlation between intercept and slope of the random regression, while the other model restricts ...
Meuwissen Theo HE, Ødegård Jørgen, Lillehammer Marie   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source