Results 71 to 80 of about 1,163,174 (254)

Maximal information component analysis: a novel non-linear network analysis method. [PDF]

, 2013
BackgroundNetwork construction and analysis algorithms provide scientists with the ability to sift through high-throughput biological outputs, such as transcription microarrays, for small groups of genes (modules) that are relevant for further research ...
Bennett, Brian, Lusis, Aldons J, Orozco, Luz D, Rau, Christoph D, Weiss, James, Wisniewski, Nicholas   +5 more
core   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Gene-gene and gene-environment interactions of CYP19A1, ESR1, IL6, IL6R, IL1β, RANK, and RANKL variants in relation to osteoporosis and hip fracture risk in Mexican women

Frontiers in Aging
BackgroundOsteoporosis is a complex disease influenced by genetic variants, environmental factors, and comorbidities. While individual single-nucleotide variants (SNVs) have been associated with disease risk, limited data are available on how gene–gene ...
Antonio Miranda-Duarte, Valeria Ponce de León-Suárez, Alberto Hidalgo-Bravo, Rafael Velázquez-Cruz, Esperanza Ramírez-Pérez, O. Celeste Martínez-Ramírez, Clementina Castro-Hernández, Blanca Barredo-Prieto, Leonora Casas-Avila   +8 more
doaj   +1 more source

Social Integration and Sleep Disturbance: A Gene-Environment Interaction Study

Collabra, 2016
Objective: Low levels of perceived social integration, or loneliness, are associated with increased risk for a range of poor health outcomes. Sleep disturbance plays a central role in the evolutionary theory of loneliness, which provides a mechanistic ...
David A. Sbarra
doaj   +1 more source

Requirement of a Plasmid-Encoded Catalase for Survival of \u3cem\u3eRhizobium etli\u3c/em\u3e CFN42 in a Polyphenol-Rich Environment [PDF]

, 2008
Nitrogen-fixing bacteria collectively called rhizobia are adapted to live in polyphenol-rich environments. The mechanisms that allow these bacteria to overcome toxic concentrations of plant polyphenols have not been clearly elucidated.
Brom, Susana, Cubillas, Ciro A., García-de los Santos, Alejandro, López, Erika, Noel, K. Dale, Romero, David   +5 more
core   +1 more source

Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]

, 2016
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R, Guidotti, Alessandro, MATRISCIANO, FRANCESCO, NICOLETTI, Ferdinando, PANACCIONE, ISABELLA   +4 more
core   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

BMC Medical Genomics, 2021
Background Gamma-aminobutyric acid type A (GABAA) receptors mainly mediate the effects of gamma-aminobutyric acid, which is the primary inhibitory neurotransmitter in the central nervous system.
Sheue-Jane Hou, Shih-Jen Tsai, Po-Hsiu Kuo, Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Eugene Lin, Tsuo-Hung Lan   +7 more
doaj   +1 more source

Environmental and genetic influences on early attachment [PDF]

, 2009
Attachment theory predicts and subsequent empirical research has amply demonstrated that individual variations in patterns of early attachment behaviour are primarily influenced by differences in sensitive responsiveness of caregivers.
Judit Gervai, J Bowlby, TB Brazelton, MDS Ainsworth, M Ainsworth, MD Ainsworth, M Main, MH van IJzendoorn, MH van IJzendoorn, S Madigan, MH van IJzendoorn, M DeWolff, J Belsky, EM Cummings, GS Gloger-Tippelt, E Moss, H Nair, M Owen, DM Teti, CH Zeanah, EK DeMulder, C Martins, L Murray, D Teti, PM Crittenden, KA Crnic, SB Crockenberg, SB Crockenberg, RA Isabella, M Main, MH van IJzendoorn, HA Raikes, Y Bar-Haim, CE Hamilton, E Waters, SL Friedman, NICHD Early Child Care Research Network, NL McElwain, NICHD Early Child Care Research Network, SB Campbell, K Lyons-Ruth, K Lyons-Ruth, K Lyons-Ruth, S Madigan, CH Zeanah, EA Carlson, G Liotti, M Main, KY Abrams, S Madigan, C Schuengel, K Lyons-Ruth, S Goldberg, JF Grienenberger, J Gervai, E Hesse, D Jacobvitz, MK Rothbart, D van den Boom, LA Sroufe, J Kagan, BE Vaughn, M Gunnar, G Spangler, G Spangler, SC Mangelsdorf, E Waters, B Egeland, K Miyake, DC van den Boom, SD Calkins, G Spangler, G Spangler, L Capps, BE Vaughn, D Barnett, D Finkel, TG O'Connor, CL Bokhorst, GI Roisman, H Minnis, R Plomin, PM Visscher, PM Visscher, M Rutter, RP Ebstein, K Lakatos, A Diamond, JN Oak, HH Van Tol, V Asghari, O Schoots, K van Craenenbroeck, SV Faraone, D Li, J Gervai, K Lakatos, MJ Bakermans-Kranenburg, MJ Bakermans-Kranenburg, M Rutter, A Caspi, A Caspi, DL Foley, J Kaufman, J Kim-Cohen, MH van IJzendoorn, S Sen, FE Lotrich, SJ Suomi, RA Barry, G Spangler, G Spangler, J Belsky, MR Munafò, MR Munafò, MJ Bakermans-Kranenburg, MJ Bakermans-Kranenburg, LR Cardon, NM Laird, TG Schulze, CS Greene, J Benjamin, MI McCarthy, MM Sánchez, G Horn, G Horn, J Bock, R Sullivan, MA Hofer, CM Kuhn, J Bock, K Becker, G Poeggel, VK Rakyan, MJ Meaney, IC Weaver, NM Cameron, FA Champagne, PO McGowan   +138 more
core   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source