Gene-environment interaction in functional hypothalamic amenorrhea [PDF]
Frontiers in EndocrinologyFunctional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea and chronic anovulation in adolescent girls and young women, diagnosed after excluding other organic causes.
Federica Barbagallo +11 more
doaj +2 more sources
Efficient gene–environment interaction testing through bootstrap aggregating [PDF]
Scientific Reports, 2023 Gene–environment (GxE) interactions are an important and sophisticated component in the manifestation of complex phenotypes. Simple univariate tests lack statistical power due to the need for multiple testing adjustment and not incorporating potential ...
Michael Lau +3 more
doaj +2 more sources
Exploring the influence of the DRD2 gene on mathematical ability: perspectives of gene association and gene-environment interaction [PDF]
BMC PsychologyMathematical ability is influenced by genes and environment. This study focused on the effect of DRD2, a candidate gene for working memory, on mathematical ability.
Qing Yang +4 more
doaj +2 more sources
Inference of gene-environment interaction from heterogeneous case-parent trios [PDF]
Frontiers in Genetics, 2023 Introduction: In genetic epidemiology, log-linear models of population risk may be used to study the effect of genotypes and exposures on the relative risk of a disease.
Pulindu Ratnasekera +2 more
doaj +2 more sources
Gene-environment interaction in the pathophysiology of type 1 diabetes [PDF]
Frontiers in EndocrinologyType 1 diabetes (T1D) is a complex metabolic autoimmune disorder that affects millions of individuals worldwide and often leads to significant comorbidities.
Rahul Mittal +4 more
doaj +2 more sources
Gene-environment interaction analysis of school quality and educational inequality [PDF]
npj Science of LearningWe study to what extent schools increase or decrease environmental and genetic influences on educational performance. Building on behavioral genetics literature on gene-environment interactions and sociological literature on the compensating and ...
Kim Stienstra +2 more
doaj +2 more sources
Mutual information for testing gene-environment interaction. [PDF]
PLoS ONE, 2009 Despite current enthusiasm for investigation of gene-gene interactions and gene-environment interactions, the essential issue of how to define and detect gene-environment interactions remains unresolved.
Xuesen Wu, Li Jin, Momiao Xiong
doaj +1 more source
Gastroenterology, 2020 BACKGROUND In contrast to most other common diseases, few genetic variants have been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that predispose to cirrhosis, to test whether such variants, aggregated into a ...
C. Emdin +14 more
semanticscholar +1 more source
A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants [PDF]
International Journal of Cancer, 2019 As a follow‐up to genome‐wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well‐known ovarian cancer risk factors and their interactions with 28 genome‐wide significant common genetic variants.
Elisa V. Bandera +63 more
openaire +6 more sources
GEM: scalable and flexible gene–environment interaction analysis in millions of samples
bioRxiv, 2020 Gene-environment interaction (GEI) studies are a general framework that can be used to identify genetic variants that modify environmental, physiological, lifestyle, or treatment effects, as well as those contributing to age, sex, racial or ethnic ...
K. Westerman +9 more
semanticscholar +1 more source