The cultural epigenetics of psychopathology: The missing heritability of complex diseases found? [PDF]
, 2009 We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders.
Wallace, Rodrick
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Social Integration and Sleep Disturbance: A Gene-Environment Interaction Study
Collabra, 2016 Objective: Low levels of perceived social integration, or loneliness, are associated with increased risk for a range of poor health outcomes. Sleep disturbance plays a central role in the evolutionary theory of loneliness, which provides a mechanistic ...
David A. Sbarra
doaj +1 more source
A new clinical evidence-based gene-environment interaction model of depression. [PDF]
, 2016 In our current understanding of mood disorders, the role of genes is diverse including the mediation of the effects of provoking and protective factors.
Bagdy, György +2 more
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]
, 2016 Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R +4 more
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Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy
Environment International, 2019 Background: Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications ...
Shangzhi Gao +9 more
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Nature, Nurture and Egalitarian Policy: What Can We Learn from Molecular Genetics? [PDF]
This brief paper draws attention to molecular genetic research which may provide a new dimension to our understanding of how socioeconomic outcomes are generated. In particular, we provide an overview of the recently emerging evidence of gene-environment
Lundborg, Petter, Stenberg, Anders
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Exploiting Gene-Environment Independence for Analysis of Case-Control Studies: An Empirical Bayes Approach to Trade Off between Bias and Efficiency [PDF]
, 2006 Standard prospective logistic regression analysis of case-control data often leads to very imprecise estimates of gene-environment interactions due to small numbers of cases or controls in cells of crossing genotype and exposure.
Mukherjee, Bhramar
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