Results 121 to 130 of about 1,095,697 (331)

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Differential Misclassification and the Assessment of Gene-Environment Interactions in Case-Control Studies [PDF]

open access: bronze, 1998
Montserrat García‐Closas   +2 more
openalex   +1 more source

Expanding the modern synthesis II: Formal perspectives on the inherent role of niche construction in fitness [PDF]

open access: yes, 2010
Expanding the modern synthesis requires elevating the role of interaction within and across various biological scales to the status of an evolutionary principle.
Rodrick Wallace
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Behavioral Phenotypes in Schizophrenic Animal Models With Multiple Combinations of Genetic and Environmental Factors

open access: yesJournal of Pharmacological Sciences, 2013
Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection ...
Hirotake Hida   +2 more
doaj   +1 more source

Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing [PDF]

open access: bronze, 1999
Jae-Gahb Park   +3 more
openalex   +1 more source

An agent-based simulation framework for complex systems [PDF]

open access: yes, 2012
In this abstract we present a new approach to the simulation of complex systems as biological interaction networks, chemical reactions, ecosystems, etc.
Benso, Alfredo   +4 more
core  

Gene/Environment Interaction and Autoimmune Disease

open access: yes, 2019
Autoimmune diseases are complex illnesses in which the body’s immune system attacks its own healthy tissues. These diseases, which can be fatal, gravely impact the quality of life of those afflicted by them with no cure currently available. The exact etiology of autoimmune diseases is not completely clear.
Harris, Tamia A, Bel, Shai
openaire   +2 more sources

Home - About - Disclaimer - Privacy