Results 151 to 160 of about 1,127,640 (282)

Supplemental Figure 1 from Assessment of Multifactor Gene–Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors

, 2023
Joseph Usset, Rama Raghavan, Jonathan Tyrer, Valerie McGuire, Weiva Sieh, Penelope M. Webb, Jenny Chang‐Claude, Anja Rudolph, Hoda Anton‐Culver, Andrew Berchuck, Louise A. Brinton, Julie M. Cunningham, Anna deFazio, Jennifer A. Doherty, Robert P. Edwards, Simon A. Gayther, Aleksandra Gentry‐Maharaj, Marc T. Goodman, Estrid Høgdall, Allan Jensen, Sharon E. Johnatty, Lambertus A. Kiemeney, Susanne K. Kjær, Melissa C. Larson, Galina Lurie, Leon F.A.G. Massuger, Usha Menon, Francesmary Modugno, Kirsten B. Moysich, Roberta B. Ness, Malcolm C. Pike, Susan J. Ramus, Mary Anne Rossing, Joseph H. Rothstein, Honglin Song, Pamela J. Thompson, David J. Van Den Berg, Robert A. Vierkant, Shan Wang‐Gohrke, Nicolas Wentzensen, Alice S. Whittemore, Lynne R. Wilkens, Anna H. Wu, Hannah Yang, Celeste Leigh Pearce, Joellen M. Schildkraut, Paul D.P. Pharoah, Ellen L. Goode, Brooke L. Fridley   +48 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Supplementary Table 5 from Characterization of Gene–Environment Interactions for Colorectal Cancer Susceptibility Loci [PDF]

, 2023
Carolyn M. Hutter, Jenny Chang‐Claude, Martha L. Slattery, Bethann M. Pflugeisen, Yi Lin, David Duggan, Hongmei Nan, Mathieu Lemire, Jagadish Rangrej, Jane C. Figueiredo, Shuo Jiao, Tabitha A. Harrison, Yan Liu, Lin Chen, Deanna L. Stelling, Greg S. Warnick, Michael Hoffmeister, Sébastien Küry, Charles S. Fuchs, Edward L. Giovannucci, Aditi Hazra, Peter Kraft, David J. Hunter, Steven Gallinger, Brent W. Zanke, Hermann Brenner, Bernd Frank, Jing Ma, Cornelia M. Ulrich, Emily White, Polly A. Newcomb, Charles Kooperberg, Andrea Z. LaCroix, Ross L. Prentice, Rebecca D. Jackson, Robert Schoen, Stephen J. Chanock, Sonja I. Berndt, Richard B. Hayes, Bette J. Caan, John D. Potter, Li Hsu, Stéphane Bezieau, Andrew T. Chan, Thomas J. Hudson, Annette Peters   +45 more
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Integrating epidemiology and genetic association: the challenge of gene–environment interaction

, 2005
Peter Kraft, David J. Hunter
openalex   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source