Epigenetic metaphors: an interdisciplinary translation of encoding and decoding
New Genetics and Society, 2019 Looking at the new and often disputed science of epigenetics, we examined the challenges faced by scientists when they communicate scientific research to the public. We focused on the use of metaphors to illustrate notions of epigenetics and genetics. We
Aviad Raz +2 more
doaj +1 more source
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
FEBS Letters, EarlyView.Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
A new clinical evidence-based gene-environment interaction model of depression. [PDF]
, 2016 In our current understanding of mood disorders, the role of genes is diverse including the mediation of the effects of provoking and protective factors.
Bagdy, György +2 more
core
Effects of Gene-Environment Interaction on Obesity among Chinese Adults Born in the Early 1960s [PDF]
, 2021 Weiyan Gong +8 more
openalex +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Random regression models for detection of gene by environment interaction
Genetics Selection Evolution, 2007 Two random regression models, where the effect of a putative QTL was regressed on an environmental gradient, are described. The first model estimates the correlation between intercept and slope of the random regression, while the other model restricts ...
Meuwissen Theo HE +2 more
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Robustness of meta-analyses in finding gene × environment interactions. [PDF]
PLoS ONE, 2017 Meta-analyses that synthesize statistical evidence across studies have become important analytical tools for genetic studies. Inspired by the success of genome-wide association studies of the genetic main effect, researchers are searching for gene ...
Gang Shi, Arye Nehorai
doaj +1 more source
The cultural epigenetics of psychopathology: The missing heritability of complex diseases found? [PDF]
, 2009 We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders.
Wallace, Rodrick
core +1 more source
Cross-cultural comparison of genetic and cultural transmission of smoking initiation using an extended twin kinship model [PDF]
, 2018 Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior.
Eaves, Lindon J +6 more
core +2 more sources
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source