Results 71 to 80 of about 1,144,749 (288)

Epigenetic metaphors: an interdisciplinary translation of encoding and decoding

New Genetics and Society, 2019
Looking at the new and often disputed science of epigenetics, we examined the challenges faced by scientists when they communicate scientific research to the public. We focused on the use of metaphors to illustrate notions of epigenetics and genetics. We
Aviad Raz, Gaëlle Pontarotti, Jonathan B. Weitzman   +2 more
doaj   +1 more source

Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation [PDF]

, 2012
BACKGROUND: Risk factors for suicide are at least partially heritable and functional polymorphisms of targeted genes have been suggested to be implicated in the pathogenesis of this phenomenon.
BORRO, Marina, D. A. Lamis, GENTILE, Giovanna, GIRARDI, Paolo, LALA, NOEMI, M. Innamorati, MARTELLETTI, Paolo, NEGRO, ANDREA, POMPILI, Maurizio, SERAFINI, Gianluca, SIMMACO, Maurizio   +10 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Gene-gene and gene-environment interactions of CYP19A1, ESR1, IL6, IL6R, IL1β, RANK, and RANKL variants in relation to osteoporosis and hip fracture risk in Mexican women

Frontiers in Aging
BackgroundOsteoporosis is a complex disease influenced by genetic variants, environmental factors, and comorbidities. While individual single-nucleotide variants (SNVs) have been associated with disease risk, limited data are available on how gene–gene ...
Antonio Miranda-Duarte, Valeria Ponce de León-Suárez, Alberto Hidalgo-Bravo, Rafael Velázquez-Cruz, Esperanza Ramírez-Pérez, O. Celeste Martínez-Ramírez, Clementina Castro-Hernández, Blanca Barredo-Prieto, Leonora Casas-Avila   +8 more
doaj   +1 more source

Gene–environment interactions in asthma [PDF]

Occupational and Environmental Medicine, 2006
Asthma is a complex disease with a diverse genetic and environmental component.1 Asthma shows a high level of phenotypic heterogeneity characterised by obstruction of the airways of the lung and is related with atopy, bronchial hyperresponsiveness (BHR), and increased IgE levels.
F, Castro-Giner, F, Kauffmann, R, de Cid, M, Kogevinas   +3 more
openaire   +2 more sources

Cross-cultural comparison of genetic and cultural transmission of smoking initiation using an extended twin kinship model [PDF]

, 2018
Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior.
Eaves, Lindon J, Heath, Andrew C, Kendler, Kenneth S, Maes, Hermine H, Martin, Nicholas G, Morley, Kate, Neale, Michael C   +6 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Random regression models for detection of gene by environment interaction

Genetics Selection Evolution, 2007
Two random regression models, where the effect of a putative QTL was regressed on an environmental gradient, are described. The first model estimates the correlation between intercept and slope of the random regression, while the other model restricts ...
Meuwissen Theo HE, Ødegård Jørgen, Lillehammer Marie   +2 more
doaj   +1 more source

Robustness of meta-analyses in finding gene × environment interactions. [PDF]

PLoS ONE, 2017
Meta-analyses that synthesize statistical evidence across studies have become important analytical tools for genetic studies. Inspired by the success of genome-wide association studies of the genetic main effect, researchers are searching for gene ...
Gang Shi, Arye Nehorai
doaj   +1 more source

Gene environment interactions in asthma [PDF]

Archives of Disease in Childhood, 2007
The underlying pathogenesis of asthma, one of the most common chronic diseases of childhood, is not fully understood. There is a well-documented heritable component to this disease and environmental factors associated with a Westernised lifestyle have also been implicated; recent studies suggest gene-environment interactions are important in the ...
S, McLeish, S W, Turner
openaire   +2 more sources