Results 131 to 140 of about 2,560,285 (288)

Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits. [PDF]

PLoS Genet, 2023
Evans LM, Arehart CH, Grotzinger AD, Mize TJ, Brasher MS, Stitzel JA, Ehringer MA, Hoeffer CA.   +7 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene-gene interaction of longevity-related loci. [PDF]

Aging Cell, 2023
Dato S, De Rango F, Crocco P, Pallotti S, Belloy ME, Le Guen Y, Greicius MD, Passarino G, Rose G, Napolioni V.   +9 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Cell Cycle Control Gene-Gene Interaction Model in Pregnancy Loss

Online Journal of Health & Allied Sciences, 2016
Early stages of individual development are defined by active cell division and differentiation processes. Intercellular signaling molecules as well as proliferation control and DNA stabilizing factors act as basic functional groups.
Mashkina EV, Kovalenko KA, Butenko EV, Shkurat TP   +3 more
doaj  

Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. [PDF]

Eur J Med Res, 2022
Rosenberger A, Muttray N, Hung RJ, Christiani DC, Caporaso NE, Liu G, Bojesen SE, Le Marchand L, Albanes D, Aldrich MC, Tardon A, Fernández-Tardón G, Rennert G, Field JK, Davies MPA, Liloglou T, Kiemeney LA, Lazarus P, Wendel B, Haugen A, Zienolddiny S, Lam S, Schabath MB, Andrew AS, Duell EJ, Arnold SM, Goodman GE, Chen C, Doherty JA, Taylor F, Cox A, Woll PJ, Risch A, Muley TR, Johansson M, Brennan P, Landi MT, Shete SS, Amos CI, Bickeböller H, INTEGRAL-ILCCO Consortium.   +40 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants. [PDF]

Biomed Res Int, 2022
Mei H, Yin B, Yang W, Zhang J, Lu H, Qi X, Mei W, Zhang H, Zhang J.   +8 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Correction: Confounding of linkage disequilibrium patterns in large scale DNA based gene-gene interaction studies. [PDF]

BioData Min, 2022
Joiret M, Mahachie John JM, Gusareva ES, Van Steen K.   +3 more
europepmc   +1 more source