Results 241 to 250 of about 2,560,285 (288)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

RNA sequencing-derived gene co-expression and drug-gene interaction analysis reveal STAT1 as a potential therapeutic target in thrombotic antiphospholipid syndrome. [PDF]

Front Immunol
Baltsiotis M, Verrou KM, Sfikakis PP, Tektonidou MG.   +3 more
europepmc   +1 more source

ODin (Orthology Data driven Interaction) Predictor: A Client‑Side Web Application for Unveiling Biological Connections Through Orthology from Alliance of Genome Resources. [PDF]

MicroPubl Biol
Cho J, Sternberg PW.
europepmc   +1 more source

CGPA: A Multicontext Cancer Gene Prognosis Atlas. [PDF]

Mol Cancer Res
Cao B, Yu X, Gonzalez G, Murthy AR, Li T, Shen Y, Yao S, Wang X.   +7 more
europepmc   +1 more source

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Analysis of Gene‐Gene Interactions

Current Protocols in Human Genetics, 2017
AbstractThe goal of this unit is to introduce epistasis, or gene‐gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene‐gene interactions ...
Brian S, Cole, Molly A, Hall, Ryan J, Urbanowicz, Diane, Gilbert-Diamond, Jason H, Moore   +4 more
openaire   +2 more sources

Assessing Gene-Gene Interactions in Pharmacogenomics

Molecular Diagnosis & Therapy, 2012
In pharmacogenomics studies, gene-gene interactions play an important role in characterizing a trait that involves complex pharmacokinetic and pharmacodynamic mechanisms, particularly when each involved feature only demonstrates a minor effect. In addition to the candidate gene approach, genome-wide association studies (GWAS) are widely utilized to ...
Hsien-Yuan, Lane, Guochuan E, Tsai, Eugene, Lin   +2 more
openaire   +2 more sources