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2012
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng +3 more
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Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng +3 more
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Extracting Gene-Gene Interactions Through Curve Fitting
IEEE Transactions on NanoBioscience, 2012This paper presents a simple and novel curve fitting approach for generating simple gene regulatory subnetworks from time series gene expression data. Microarray experiments simultaneously generate massive data sets and help immensely in the large-scale study of gene expression patterns.
Ranajit, Das +2 more
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Analysis of Gene‐Gene Interactions
Current Protocols in Human Genetics, 2003AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
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Gene-Gene, Gene-Environment & Multiple Interactions in Colorectal Cancer
Journal of Environmental Science and Health, Part C, 2006This review comprehensively evaluates the influence of gene-gene, gene-environment and multiple interactions on the risk of colorectal cancer (CRC). Methods of studying these interactions and their limitations have been discussed herein. There is a need to develop biomarkers of exposure and of risk that are sensitive, specific, present in the pathway ...
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Pharmacogenomics, 2010
In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study.
Patricia, Gassó +7 more
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In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study.
Patricia, Gassó +7 more
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Gene-gene interactions in myocardial infarction
The Lancet, 2006www.thelancet.com Vol 367 May 27, 2006 1729 Shirish Sheth (Jan 21, p 185) rightly decries the appalling fact that, as a result of abortion, “about 100 million girls are missing from the world—they are dead”, and properly emphasises that, since 1986, all members of the Federation of Obstetric and Gynaecological Societies of India have been “asked to ...
Gilles Pernod +2 more
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Detecting Gene‐Gene Interaction in Linkage Analysis
Current Protocols in Human Genetics, 2005AbstractLinkage analysis has been very successful in identifying genes for many Mendelian diseases, but has not enjoyed the same level of success for complex diseases. A major reason is that complex diseases are multifactorial, involving multiple genes and environmental factors.
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Gene-Gene and Gene-Environment Interactions
2018Identifying gene-gene and gene-environment interactions may help us to better describe the genetic architecture for complex traits. While advances have been made in identifying genetic variants associated with complex traits through more dense panels of genetic variants and larger sample sizes, genome-wide interaction analyses are still limited in ...
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Case-Only Design to Measure Gene-Gene Interaction
Epidemiology, 1999The case-only design is an efficient and valid approach to screening for gene-environment interaction under the assumption of the independence between exposure and genotype in the population. In this paper, we show that the case-only design is also a valid and efficient approach to measuring gene-gene interaction under the assumption that the ...
Q, Yang +3 more
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Testing for Gene-Gene Interaction with AMMI Models
Statistical Applications in Genetics and Molecular Biology, 2010Studies have shown that many common diseases are influenced by multiple genes and their interactions. There is currently a strong interest in testing for association between combinations of these genes and disease, in particular because genes that affect the risk of disease only in the presence of another genetic variant may not be detected in marginal
Amina, Barhdadi, Marie-Pierre, Dubé
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