Results 71 to 80 of about 2,560,285 (288)

Gene–gene interaction associated with neural reward sensitivity [PDF]

Proceedings of the National Academy of Sciences, 2007
Reward processing depends on dopaminergic neurotransmission and is modulated by factors affecting dopamine (DA) reuptake and degradation. We used fMRI and a guessing task sensitive to reward-related activation in the prefrontal cortex and ventral striatum to study how individual variation in genes contributing to DA reuptake [DA transporter (DAT)] and ...
Juliana, Yacubian, Tobias, Sommer, Katrin, Schroeder, Jan, Gläscher, Raffael, Kalisch, Boris, Leuenberger, Dieter F, Braus, Christian, Büchel   +7 more
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The role of genetic variability in the GABRA6, 5-HTT and BDNF genes in anxiety-related traits [PDF]

, 2012
Objective:  The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brain-derived neurotrophic factor gene (BDNF) and the GABAAα6 receptor subunit gene (GABRA6) with anxiety-related traits and to ...
Aguilera, Mari, Arias, Barbara, Bobes García, Julio, Fañanás Saura, Lourdes, García-Portilla González, María Paz, 1962-, Ibáñez, Manuel I, Moya-Higueras, Jorge, Ortet, Generós, Sáiz Martínez, Pilar Alejandra, Villa Martín, Elena   +9 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pathway-guided identification of gene-gene interactions. [PDF]

Annals of human genetics, 2015
Assessing gene-gene interactions (GxG) at the gene level can permit examination of epistasis at biologically functional units with amplified interaction signals from marker-marker pairs. While current gene-based GxG methods tend to be designed for two or a few genes, for complex traits, it is often common to have a list of many candidate genes to ...
Xin, Wang, Daowen, Zhang, Jung-Ying, Tzeng   +2 more
openaire   +3 more sources

Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. [PDF]

, 2020
BackgroundGlobal gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a disease and treatment-specific ...
Burchard, Esteban G, Croteau-Chonka, Damien C, Dahlin, Amber, Eng, Celeste, Kelly, Rachel, Kho, Alvin T, Lu, Quan, Lutz, Sharon M, Mak, Angel CY, McGeachie, Michael J, Oh, Sam S, Panganiban, Ronald, Raby, Benjamin A, Rodriguez-Santana, Jose R, Saef, Benjamin, Sajuthi, Satria, Seibold, Max A, Sordillo, Joanne E, Tantisira, Kelan G, Urbanek, Cydney, Wang, Alberta L, Weiss, Scott T, Wu, Ann Chen   +22 more
core   +1 more source

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene [PDF]

, 2017
Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene.
Catchpole, B, Church, D B, Forcada, Y, Fowkes, R C, Niessen, S J M, Scudder, C J   +5 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

CREaTor: zero-shot cis-regulatory pattern modeling with attention mechanisms

Genome Biology, 2023
Linking cis-regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis-regulatory patterns for genomic elements up to 2 Mb from target genes ...
Yongge Li, Fusong Ju, Zhiyuan Chen, Yiming Qu, Huanhuan Xia, Liang He, Lijun Wu, Jianwei Zhu, Bin Shao, Pan Deng   +9 more
doaj   +1 more source

Gene-Gene Interactions Detection Using a Two-Stage Model [PDF]

Journal of Computational Biology, 2014
Genome-wide association studies (GWAS) have discovered numerous loci involved in genetic traits. Virtually all studies have reported associations between individual single nucleotide polymorphisms (SNPs) and traits. However, it is likely that complex traits are influenced by interaction of multiple SNPs.
Zhanyong, Wang, Jae Hoon, Sul, Sagi, Snir, Jose A, Lozano, Eleazar, Eskin   +4 more
openaire   +2 more sources