Results 101 to 110 of about 3,924,229 (269)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Protein kinase Pi65 regulates rice blast resistance through phosphorylation-dependent signaling and metabolic reprogramming

Frontiers in Genetics
Rice blast is a major fungal disease that threatens global rice production and is caused by the fungus Magnaporthe oryzae. Therefore, cloning rice blast resistance-related genes, conducting indepth analyses of the interaction mechanisms between M. oryzae
Lili Wang, Hongwei Chen, Xiaohang Zhou, Bowen Yan, Zhiqiang Tang, Zuobin Ma, Dianrong Ma, Wenjing Zheng   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

THE COMPARATIVE MOLECULAR GENETICAL STUDY OF ASIAN POPULATIONS OF DROSOPHILA MERCATORUM (DIPTERA; DROSOPHILIDAE) ON THE COI GENE AND ITS1-ITS2 rRNA GENES FRAGMENTS

Вавиловский журнал генетики и селекции, 2015
The Drosophila mercatorum species of neotropical origin is composed of two subspecies: mercatorum and pararepleta. The D. m. mercatorum subspecies is synanthropic. It appeared in Eurasia in the middle of the 20th century and dispersed widely. The objects
A. V. Ivannikov, O. V. Vaulin, Yu. A. Koromyslov, I. K. Zakharov   +3 more
doaj  

Identification of Candidate Genes for Soybean Storability via GWAS and WGCNA Approaches

Agronomy
Soybean (Glycine max (L.) Merr.) is an important crop for both food and feed, playing a significant role in agricultural production and the human diet.
Xu Wu, Yuhe Wang, Jiapei Xie, Zhenhong Yang, Haiyan Li, Yongguang Li, Weili Teng, Xue Zhao, Yuhang Zhan, Yingpeng Han   +9 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mechanism of ABA in Plants Exposed to Cold Stress

Agronomy
Abscisic acid (ABA) is a natural hormone produced in plants, which plays an important role in plant growth and development and in response to adversity. Increasing research indicates that ABA is involved in plant response to cold stress and enhances the ...
Changxia Li, Yuna Pan, Jing Cui, Xuefang Lu, Wenjin Yu   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Two Different Brain Injury Patterns Associated with Compound Heterozygosis of the PIGO Gene in a Term Newborn: A Case Report

Biomedicines
The glycosylphosphatidylinositol (GPI) is a glycol–lipid that anchors several proteins to the cell surface. The GPI-anchor pathway is crucial for the correct function of proteins involved in cell function, and it is fundamental in early neurogenesis and ...
Francesco Dellepiane, Giulia Moltoni, Sara Ronci, Alessia Guarnera, Maria Camilla Rossi-Espagnet, Maria Cristina Digilio, Diego Martinelli, Francesca Campi, Daniela Longo   +8 more
doaj   +1 more source