Results 111 to 120 of about 6,617,997 (307)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Gene Allen Oral History (part 2)
Gene Allen, Art Director of "My Fair Lady", "A Star is Born", and "Les Girls".
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in GeneticsRice blast is a major fungal disease that threatens global rice production and is caused by the fungus Magnaporthe oryzae. Therefore, cloning rice blast resistance-related genes, conducting indepth analyses of the interaction mechanisms between M. oryzae
Lili Wang +7 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Gene A. Chesley (1935-1981) was a highly regarded scenic designer, theatre historian, and teacher. Chesley taught in the Dramatic Art Deparment at the University of California Davis from 1963 until his death at age 46 in 1981.
Chesley, Gene A.
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Вавиловский журнал генетики и селекции, 2015 The Drosophila mercatorum species of neotropical origin is composed of two subspecies: mercatorum and pararepleta. The D. m. mercatorum subspecies is synanthropic. It appeared in Eurasia in the middle of the 20th century and dispersed widely. The objects
A. V. Ivannikov +3 more
doaj
Identification of Candidate Genes for Soybean Storability via GWAS and WGCNA Approaches
AgronomySoybean (Glycine max (L.) Merr.) is an important crop for both food and feed, playing a significant role in agricultural production and the human diet.
Xu Wu +9 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source