Results 91 to 100 of about 8,938,319 (306)
The Realities of K-12 Virtual Education [PDF]
, 2009 In a decade, virtual education in its contemporary form of asynchronous, computer-mediated interaction between a teacher and students over the Internet has grown from a novelty to an established mode of education that may provide all or part of formal ...
Gene V. Glass
core +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A rare intronic c.2654+1G>A mutation in CSF1R-microglial encephalopathy: a case report
Frontiers in GeneticsObjectiveWe report a case of CSF1R-microglial encephalopathy associated with a rare intronic c.2654 + 1G>A mutation, featuring negative diffusion-weighted imaging (DWI) findings and a cerebrospinal fluid (CSF) biomarker profile indicative of Alzheimer’
HongYan Wu +4 more
doaj +1 more source
Research progress in kumquat [PDF]
Guoshu xuebaoCitrus is the largest fruit crop in China. Kumquat, a small citrus fruit with important economic and scientific research value, is widely distributed across the Guangxi Zhuang Autonomous Region and Jiangxi, Hunan, Fujian and Zhejiang provinces of China ...
LIU Xu, YE Junli, DENG Xiuxin
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in MedicineObjectivePrimary angle-closure glaucoma (PACG), an incurable ophthalmic disease, is a serious risk to human visual health. Previous studies have demonstrated a strong link between PACG and neuroimaging changes in the brain.
Yuan Hu +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Česká Stomatologie a Praktické Zubní Lékařství, 2009 Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder characterized by severe early-onset periodontal destruction involving both the deciduous and permanent dentition and skin lesions of palmoplantar hyperkeratosis. Recently it was found
L. Izakovičová Hollá +3 more
doaj
Association of overexpression of PLD6, CHRAC1 and PDCD5 with type 2 diabetes mellitus
Medicinski GlasnikAim Diabetes type 2 (DT2) is a metabolic disease characterized by high blood sugar caused by insulin resistance and/or insufficient insulin production. The pathogenesis of DT2 is complicated by both genetic predisposition and environmental and lifestyle ...
Ali Adel Dawood +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source