Results 81 to 90 of about 8,938,319 (306)

Constitutional Perils—Real and Otherwise [PDF]

open access: yes, 1984
Review of: Our Endangerd Rights—The ACLU Report on Civil Liberties Today. Edited with an Introduction by Norman Dorsen.
Nichol, Gene R., Jr.
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Association of single nucleotide variants of the SLCO1B1 gene with the Gilbert syndrome phenotype

open access: yesБюллетень сибирской медицины
The aim of the study is to investigate the association of rs2306283 and rs4149056 variants of the SLCO1B1 gene with benign unconjugated hyperbilirubinemia. Materials and methods. A case-control study design was employed.
A. A. Ivanova   +7 more
doaj   +1 more source

Taking Economic Equality Off the Table [PDF]

open access: yes, 2000
Nichol considers Pres Clinton\u27s Administration\u27s record on issues of economic equality, including California Gov Pete Wilson\u27s plan to discriminate against newly arrived California welfare recipients.
Nichol, Gene R.
core   +2 more sources

The gene: An appraisal

open access: yesProgress in Biophysics and Molecular Biology, 2021
The gene can be described as the foundational concept of modern biology. As such, it has spilled over into daily discourse, yet it is acknowledged among biologists to be ill-defined. Here, following a short history of the gene, I analyse critically its role in inheritance, evolution, development, and morphogenesis.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Polymorphism detection of catalase-21A\T (rs 7943316) gene in chronic myeloid leukemia patients infected with human herpes virus-7

open access: yesIraqi Journal of Hematology
BACKGROUND: Chronic myeloid leukemia (CML) is a type of cancer that originates in hematopoietic stem cells, particularly those that develop into myeloid cells.
Yusur Falah Faraj
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM

open access: yesМедицинская иммунология, 2014
Taking into account interrelations between inflammation and hemostasis, as well as immediate effects of IL-1β, IL-6 and TNFα upon blood coagulation system, one may suggest that their functional variantscould determine thrombosis risks both in arterial ...
A. P. Polyakova   +6 more
doaj   +1 more source

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