Results 161 to 170 of about 16,521,028 (347)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Gene expression profile of human lung in a relatively early stage of COPD with emphysema

International Journal of COPD, 2018
Ina Jeong,1,* Jae-Hyun Lim,2,* Dong Kyu Oh,3 Woo Jin Kim,4 Yeon-Mok Oh3 1Department of Internal Medicine, National Medical Center, Seoul, Republic of Korea; 2Biomedical Informatics Research Center, Division of Biomedical Informatics, Seoul National ...
Jeong I, Lim JH, Oh DK, Kim WJ, Oh YM
doaj  

The B-Box Family Gene STO (BBX24) in Arabidopsis thaliana Regulates Flowering Time in Different Pathways

, 2014
Feng Li, Jinjing Sun, Donghui Wang, Shu‐Nong Bai, Adrian K. Clarke, Magnus Holm   +5 more
openalex   +2 more sources

Gene Ontology: tool for the unification of biology

Nature Genetics, 2000
Michael Ashburner, C. Ball, J. Blake, D. Botstein, Heather L. Butler, J. Cherry, A. P. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, M. Ringwald, G. Rubin, G. Sherlock   +19 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Stability of the LATS2 Tumor Suppressor Gene Is Regulated by Tristetraprolin [PDF]

, 2010
Hyun Hee Lee, Mai‐Tram Vo, Hyo Jeong Kim, Unn Hwa Lee, Chae Won Kim, Hong Kyeung Kim, Myoung Seok Ko, Won Hyuck Lee, Seung‐Jae Joo, Young Joo Min, Dae Hwa Choi, Ho Seok Suh, Byung Ju Lee, Jeong Woo Park, Wha Ja Cho   +14 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Analysis of the Codon Usage Pattern of HA and NA Genes of H7N9 Influenza A Virus [PDF]

, 2020
Jiumeng Sun, Wen Zhao, Ruyi Wang, Wenyan Zhang, Gairu Li, Meng Lu, Yuekun Shao, Yi-Chen Yang, Ningning Wang, Qi Gao, Shuo Su   +10 more
openalex   +1 more source

clusterProfiler: an R package for comparing biological themes among gene clusters.

Omics, 2012
Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing‐Yu He   +3 more
semanticscholar   +1 more source