Results 171 to 180 of about 16,521,028 (347)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Evaluation of Polymorphism of Leu/Val of Growth Hormone Gene in Friesian Holstein Cows at Breeding Centre of Dairy Cattle Baturraden

Animal Production: Indonesian Journal of Animal Production, 2009
The Leu/Val polymorphism of the growth hormone evaluation was studied in 35 Friesian Holstein dairy cow at Baturraden Breeding Centre of Dairy Cattle. A 211 bp DNA fragment of GH gene spanning from the forth intron region (49 bp) to fifth of exon (162 bp)
MA Mu’in, N Zurahmah
doaj  

The O‐methyltransferase gene MdoOMT1 is required for biosynthesis of methylated phenylpropenes in ripe apple fruit [PDF]

, 2015
Yar‐Khing Yauk, David Chagné, Sumathi Tomes, Adam J. Matich, Mindy Wang, Xiuyin Chen, Ratnasiri Maddumage, Martin Hunt, Daryl D. Rowan, Ross G. Atkinson   +9 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Molecular Signatures Database Hallmark Gene Set Collection

, 2015
A. Liberzon, Chet Birger, H. Thorvaldsdóttir, M. Ghandi, J. Mesirov, P. Tamayo   +5 more
semanticscholar   +1 more source

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

Nature Protocols, 2012
C. Trapnell, Adam Roberts, L. Goff, G. Pertea, Daehwan Kim, David R. Kelley, Harold Pimentel, S. Salzberg, J. Rinn, L. Pachter   +9 more
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

PIK3CA Genotype and a PIK3CA Mutation-Related Gene Signature and Response to Everolimus and Letrozole in Estrogen Receptor Positive Breast Cancer

, 2013
Sherene Loi, Stefan Michiels, José Baselga, Thomas John, Sandeep K. Singhal, Vicky S. Sabine, Andrew H. Sims, Tarek Sahmoud, J. Michael Dixon, Martine Piccart, Christos Sotiriou   +10 more
openalex   +2 more sources

Discovery of new glomerular disease–relevant genes by translational profiling of podocytes in vivo [PDF]

, 2014
Ivica Grgic, Andreas Hofmeister, Giulio Genovese, Andrea J. Bernhardy, Hua Sun, Omar H. Maarouf, Vanesa Bijol, Martin R. Pollak, Benjamin D. Humphreys   +8 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source