Results 211 to 220 of about 7,655,843 (235)

Analysis of Gene‐Gene Interactions

Current Protocols in Human Genetics, 2003
AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
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Genes and Gene Complexes

1967
Mendel was ahead of his time, but he was not so far ahead that he could not arrive at the first great generalizations of genetics—his first and second laws. How fortunate that Mendel did not discover linkage, for he might then have failed to deduce the second law.
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Gene-Gene Interactions

2012
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Xiaofeng Zhu, Gang Zheng, Yaning Yang, Robert C. Elston   +3 more
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Genes within Genes

Inference: International Review of Science, 2018
A new study, “Russian Doll Genes and Complex Chromosome Rearrangements in Oxytricha trifallax,” casts fresh light on gene nesting and mathematical patterns. Tyler Hampton examines the key findings.
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Better Gene Expression by (-)Gene than by (+)Gene in Phage Gene Delivery Systems

Biotechnology Progress, 2006
In recent years, capsid-modified filamentous bacteriophage has become a potential vector for gene delivery into mammalian cells. However, little was known about how the carried gene in the single-stranded genome expressed in mammalian cells. To explore whether the orientation of the carried gene affects its expression in the cells, we prepared EGF ...
Jianren Gu, Jianren Gu, Zonghai Li, Yun Liang, Yun Liang, Jie Zhang, Bizhi Shi, Hua Jiang, Hua Jiang, Yuhong Xu   +9 more
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Tandem genes and clustered genes

Journal of Theoretical Biology, 1995
Two patterns of gene repetition are described: tandem arraying and clustering. Tandemly arrayed genes reside within segments of DNA that are repeated head-to-tail a number of times. Clustered genes are linked but irregularly spaced, are often mutually inverted in an unpredictable pattern and are connected by non-conserved DNA.
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Gene Duplication and Gene Loading

2014
During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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Sequencing Genes and Gene Islands by Gene Enrichment

2009
Access to the sequence of any gene in a genome greatly accelerates genetics research. Whole genome sequencing is a way to retrieve such information although, for large genomes such as that of maize, it represents a huge effort. Fortunately, a maize genome sequencing project is currently underway but, before this project started, the maize research ...
W. Brad Barbazuk, Pablo D. Rabinowicz
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Genes, genes, genes

The Lancet Oncology, 2013
Hogarth, Stuart, Sullivan, Richard
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Gene function, gene networks and the fate of duplicated genes

Seminars in Cell & Developmental Biology, 1999
For both copies of a duplicated gene to become fixed in a population and subsequently maintained, selection must favour individuals with both genes over individuals with one. Here I review and assess some of the proposed ways that gene structure and function might affect the likelihood of both copies acquiring distinct functions and therefore positive ...
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