Results 231 to 240 of about 6,617,997 (307)

Integrated expression profiling reveals molecular crosstalk between CFTR, FASN, FRAP (mTOR), and BANK1 in hepatocellular carcinoma. [PDF]

Sci Rep
Abbas S, Abid F, Mehmood T, Fatima S, Trembley JH, Nazli R, Aziz H, Abusharha A, Afsar T, Razak S.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Molecular study of specific virulence genes of Pseudomonas aeruginosa isolated from sub clinical bovine mastitis cases. [PDF]

Sci Rep
Ibrahim ES, Dorgham SM, Eid RH, Abdel-Latif EF, Khalaf DD.   +4 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mutation Pressure and Gene-Specific Selection Shape Codon Usage Bias in the Chloroplast Genomes of <i>Isoetes</i>, an Ancient Aquatic Vascular Plant Lineage. [PDF]

Ecol Evol
Li B, Xue Y, Zhang D, Smagghe G, Liang S, Wang S, Ge Y, Aimaitijiang Z, Gai Y.   +8 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Identification of immune cell type-specific susceptibility genes in multiple cancers using transcriptome-wide association studies. [PDF]

J Natl Cancer Inst
Qin F, Hua X, Wang X, Zhang H, Choi J, Yang XR, Zhang T, Machiela MJ, Anyaso-Samuel S, Landi MT, Berndt SI, Purdue MP, Albanes D, Zhu B, Brown KM, Shi J, Yu K.   +16 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes. [PDF]

Proc Natl Acad Sci U S A
van Thiel J, Dowell NL, Smith CF, Sanchez EE, Carroll SB.   +4 more
europepmc   +1 more source

Gene Expression, Pathway Analysis, and Drug Discovery of Neurofibromatosis 2 Vestibular Schwannomas

Translation
Mark Houdi, Hunter Eby, Ali Imami
doaj   +1 more source