Results 261 to 270 of about 5,291,226 (319)

Comparative transcriptomics of anthocyanin accumulation in the pericarp of pigmented purple corn. [PDF]

Theor Appl Genet
Holly AA, Michael PN, John JA.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Genome-Wide Identification and Systematic Analysis of the <i>HSF</i> Gene Family in <i>Capparis spinosa</i> and Its Expression Under High Temperature. [PDF]

Int J Mol Sci
Li L, Zhang R, Tuohtarbek A, Cheng C.
europepmc   +1 more source

Improved in vivo gene knockout with high specificity using multiplexed Cas12a sgRNAs. [PDF]

Nat Commun
Port F, Buhmann MA, Zhou J, Stricker M, Vaughan-Brown A, Michalsen AC, Roßmanith E, Pöltl A, Großkurth L, Huber J, Menendez Kury LB, Weberbauer B, Hübl M, Puscher E, Heigwer F, Boutros M.   +15 more
europepmc   +1 more source

Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer's Disease. [PDF]

Glia
Abhyankar SD, Xiao Y, Mahajan N, Luo Q, Cummins TR, Oblak AL, Lamb BT, Corson TW, Bhatwadekar AD.   +8 more
europepmc   +1 more source

Genome-wide identification, characterization, and expression analyses of the solute carrier 2 (SLC2) gene family in fall armyworm (Spodoptera frugiperda). [PDF]

BMC Genomics
Zoghly HM, Ghallab AMK, Emam MM, Abdelbaky MA, Rashed MA, El-Sayed W, Abdelmaksoud EM.   +6 more
europepmc   +1 more source

Correction to "The Safety of Soy Leghemoglobin Protein Preparation Derived from <i>Pichia pastoris</i> Expressing a Soy Leghemoglobin Gene from <i>Glycine max</i>: <i>In Vitro</i> and <i>In Vivo</i> Studies". [PDF]

J Toxicol
europepmc   +1 more source