Results 261 to 270 of about 16,521,028 (347)

Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency. [PDF]

Sci Rep
Ladd B, Tunmats S, Gräslund T, Daramola O, Rockberg J, Chotteau V.   +5 more
europepmc   +1 more source

BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks

Bioinform., 2005
Steven Maere, Karel Heymans, Martin Kuiper   +2 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A chromosome-level genome of Astilbe chinensis unveils the evolution of a terpene biosynthetic gene cluster. [PDF]

Nat Commun
Chen F, Yao Y, Zhu H, Hu J, Geng A, Xu Z, Fang X, Cheng W, Zhi Y, Zhang Y, Deng Z, Liu T, Lu L.   +12 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Complementary Roles of DNA Methylation and miRNA in Regulating Gene Expression Under Environmental Stress in Biological Invasions. [PDF]

Evol Appl
Yan W, Fu R, Huang X, Zhan A.
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Editorial: The role of genes and network pharmacology in new drug discovery

Frontiers in Genetics
Jingxin Mao, Jingxin Mao
doaj   +1 more source

THRESHOLD: a comprehensive transcriptomic analysis tool for evaluating gene saturation and impact in disease progression. [PDF]

NAR Cancer
Gammell F, Li J, Elco C, Plavicki J, Uzun A.   +4 more
europepmc   +1 more source

Global analysis of the metaplasmidome: ecological drivers and spread of antibiotic resistance genes across ecosystems [PDF]

Didier Debroas
openalex   +1 more source