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Gene-gene and gene-environment interactions in lipodystrophy
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically ...
Broekema, M. F. +3 more
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Sequencing Genes and Gene Islands by Gene Enrichment
2009Access to the sequence of any gene in a genome greatly accelerates genetics research. Whole genome sequencing is a way to retrieve such information although, for large genomes such as that of maize, it represents a huge effort. Fortunately, a maize genome sequencing project is currently underway but, before this project started, the maize research ...
Pablo D. Rabinowicz, W. Brad Barbazuk
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A Gene-Based Approach for Testing Gene × Gene and Gene × Environment Interactions
2016The importance of the gene × gene (G × G) and gene × environment (G × E) interaction has been widely recognized. It is statistically challenging to account for interactions in the analysis of genome-wide association data. In this chapter, we introduce a gene-based method for modeling G × G and G × E interactions under the regression framework.
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Regulation of genome organization and gene expression by nuclear mechanotransduction
Nature Reviews Molecular Cell Biology, 2017G V Shivashankar, Caroline Uhler
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mRNAs, proteins and the emerging principles of gene expression control
Nature Reviews Genetics, 2020Christopher Buccitelli +1 more
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Regulation of chromatin and gene expression by metabolic enzymes and metabolites
Nature Reviews Molecular Cell Biology, 2018Shelley Berger +2 more
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