Results 281 to 290 of about 5,255,551 (319)

Gene Duplication and Gene Loading

2014
During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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Gene function, gene networks and the fate of duplicated genes

Seminars in Cell & Developmental Biology, 1999
For both copies of a duplicated gene to become fixed in a population and subsequently maintained, selection must favour individuals with both genes over individuals with one. Here I review and assess some of the proposed ways that gene structure and function might affect the likelihood of both copies acquiring distinct functions and therefore positive ...
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Gene-gene and gene-environment interactions in lipodystrophy

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019
Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically ...
Broekema, M. F., Savage, D. B., Monajemi, H., Kalkhoven, E.   +3 more
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Genes, genes, genes

The Lancet Oncology, 2013
Hogarth, Stuart, Sullivan, Richard
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Gene-Gene Interactions

2012
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng, Yaning Yang, Xiaofeng Zhu, Robert C. Elston   +3 more
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Cancer epigenetics in clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Veronica Davalos, Manel Esteller
exaly  

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Genes, Genes, and More Genes

Human Gene Therapy, 1994
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A Gene-Based Approach for Testing Gene × Gene and Gene × Environment Interactions

2016
The importance of the gene × gene (G × G) and gene × environment (G × E) interaction has been widely recognized. It is statistically challenging to account for interactions in the analysis of genome-wide association data. In this chapter, we introduce a gene-based method for modeling G × G and G × E interactions under the regression framework.
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Genes and Gene Families Related to Immunoglobulin Genes

1987
The vertebrate immune response involves two major classes of effector cells: T lymphocytes and B lymphocytes. In recent years, the molecules involved in antigen recognition and cell-cell interactions of T and B lymphocytes have been defined at the molecular level.
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