Results 291 to 300 of about 16,521,028 (347)

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Transformer-based representation learning for robust gene expression modeling and cancer prognosis. [PDF]

Sci Rep
Jiang S, Hassanpour S.
europepmc   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

A novel spatial framework to validate arsenic exposure gene expression profiling in bladder cancer using multiplex FISH and AI-powered digital pathology. [PDF]

Sci Rep
Singhal S, Singhal S, Gardner KL, Dikshit A, Doolittle E, Sens D, Sens MA, Miller ML, Aung STH, Singhal SK.   +9 more
europepmc   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Gene therapy for hemophilia: results of ISTH global survey on current knowledge, attitudes, and preparedness of the hemophilia care team. [PDF]

Ther Adv Hematol
Glasner MF, Miesbach W.
europepmc   +1 more source

A lactate metabolism-related gene signature to diagnose osteoarthritis based on machine learning combined with experimental validation

Jianhua Yang, Wenjun Li, Xuemei Lin, Liang Wei   +3 more
openalex   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

A joint complex network and machine learning approach for the identification of discriminative gene communities in autistic brain. [PDF]

PLoS One
Lacalamita A, Pantaleo E, Monaco A, Bellantuono L, Fania A, La Rocca M, Maggipinto T, Tangaro S, Amoroso N, Bellotti R.   +9 more
europepmc   +1 more source

Spread and persistence of antimicrobial resistance genes in wastewater from human and animal sources in São Paulo, Brazil

Milena Dropa, Jéssica Santiago Bispo da Silva, André Furugen César Andrade, Denis Hideki Nakasone, Marcos Paulo Vieira Cunha, Gesiane Ribeiro, Ronalda Silva de Araújo, Carlos Jesus Brandão, Bárbara Ghiglione, Nilton Lincopán, Maria Inês Zanoli Sato, Terezinha Knöbl   +11 more
openalex   +1 more source