Results 101 to 110 of about 11,841,902 (391)
Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]
, 2015 OBJECTIVES: The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. METHODS: Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Berriman, Matthew +5 more
core +3 more sources
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Heterosis and gene action in okra
Bangladesh Journal of Agricultural Research, 2008 Forty two hybrids generated by crossing three testers with fourteen lines were studied along with parents for studying heterosis and gene action for days to first flowering, days to 50 percent flowering, fruit weight, fruit length, plant height, number of seeds per fruit, 100-seed weight and fruit yield per plant during rainy season and summer season ...
BS Asati, Nandan Mehta, SR Mamidwar
openaire +3 more sources
eLife, 2016 Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the alleviation of depression and anxiety. However, the exact mechanisms whereby physical exercise
Sama F. Sleiman +11 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Combining ability studies and heterosis for yield and its component traits in safflower [Carthamus tinctorius L.)] [PDF]
Electronic Journal of Plant Breeding, 2011 Evaluation of parents and F1s derived from crossing four well adapted lines and six testers in a line x tester fashion revealed that variance due to sca had higher magnitude than gca variance for all the traits studied indicating that these traits are ...
D.Shivani, Ch.Sreelakshmi and C.V. Sameer Kumar
doaj
Electronic Journal of Plant Breeding, 2017 To estimate general combining ability and specific combing ability effects for various characters eight inbred lines were crossed in 8×8 full diallel fashion.
C.D. Shrishaila +4 more
doaj +1 more source
Genes & Development, 1995 The crucifer Arabidopsis thaliana has been used widely as a model organism for the study of plant development. We describe here the development of an efficient insertional mutagenesis system in Arabidopsis that permits identification of genes by their ...
V. Sundaresan +7 more
semanticscholar +1 more source
RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer [PDF]
, 2015 Triple negative breast cancer (TNBC) is characterized by multiple genetic events occurring in concert to drive pathogenic features of the disease. Here we interrogated the coordinate impact of p53, RB, and MYC in a genetic model of TNBC, in parallel with
Ertel, Adam +5 more
core +1 more source