Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Identification of Newer Stable Genetic Sources for High Grain Number per Panicle and Understanding the Gene Action for Important Panicle Traits in Rice. [PDF]
Plants (Basel), 2023 Gunasekaran A +4 more
europepmc +1 more source
Reflections for postgraduate students on writing an action research thesis
, 2017 The prospect of conducting action research as part of formal academic study can seem quite daunting for many. The academy, often dominated by a positivist approach, does not always appreciate the value and quality of research that is qualitative, action ...
Smith, Steve Wayne
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Gene action, genetic variation, and GWAS: A user-friendly web tool. [PDF]
PLoS Genet, 2021 Hivert V, Wray NR, Visscher PM.
europepmc +1 more source
Developing environmental citizenship on campus through Action Research
, 2015 This study was designed to refine understanding of the influence of environmental education on the development of thought processes, on moral awareness and on students' ability to act as environmental citizens.
Avriel-Avni, Noa
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Combining ability and gene action controlling rust resistance in groundnut (Arachis hypogaea L.). [PDF]
Sci Rep, 2021 Daudi H +4 more
europepmc +1 more source
Facilitated action research: Enhancing the teaching of classroom drama
, 2013 This paper argues for facilitated action research as an effective way of supporting teacher professional learning in drama. It also recognises that the need for support identified in a past study remains current resulting in the facilitated action ...
Perry, Rachel
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source