Results 251 to 260 of about 11,841,902 (391)

Action of the calcium channel blocker lacidipine on cardiac hypertrophy and endothelin‐1 gene expression in stroke‐prone hypertensive rats [PDF]

, 1996
Olivier Féron, Salvatore Salomone, Théophile Godfraind   +2 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Acute nuclear actions of growth hormone (GH): cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression. [PDF]

, 1996
Ann M. Gronowski, Catherine Le Stunff, Peter Rotwein   +2 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Genomic Markers Distinguishing Shiga Toxin-Producing <i>Escherichia coli</i>: Insights from Pangenome and Phylogenomic Analyses. [PDF]

Pathogens
Elrefaey A, Bentum KE, Kuufire E, James T, Nyarku R, Osei V, Woube Y, Samuel T, Abebe W.   +8 more
europepmc   +1 more source

The Anti-Inflammatory Actions of the Herbal Medicine, Cat's Claw, Are Due to a Suppression of NF-κB Activation and Inhibition of Gene Expression [PDF]

, 1999
Mark J.S. Miller, Xueji Zhang, Randi M Charbonnet, David A. Clark, Manuel Sandoval   +4 more
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Evolving roles for the androgen receptor and its protein interactome in castration-resistant prostate cancer. [PDF]

Oncogene
Chukhu M, Dahiya UR, Heemers HV.
europepmc   +1 more source

Purification of theE.coliogt gene product to homogeneity and its rate of action onO⁶-methylguanine,O⁶-ethyiguanine andO⁴-methylthymine in dodecadeoxyribnucleotides

, 1989
Mark C. Wilkinson, Philip M. Potter, Lynn Cawkwell, Panagiotis Georgiadis, D. Patel, Peter Swann, G.P. Margison   +6 more
openalex   +2 more sources