Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Microbial Primer: The R-pyocins of <i>Pseudomonas aeruginosa</i>. [PDF]
Microbiology (Reading)Estrada I +4 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Long QT interval syndrome type 2 caused by a new missense mutation of KCNH2 gene: A case report. [PDF]
Medicine (Baltimore)Ma Y, Wang L, Wu S, Peng C.
europepmc +1 more source
Lysophosphatidic Acid Synergizes With 1,25-Dihydroxyvitamin D to Promote Fibroblast Growth Factor-23 Synthesis via MAPK Signaling and Induction of the IL12A Gene. [PDF]
FASEB JAy B +7 more
europepmc +1 more source
Action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine: adenine pair triggered by MUTYH. [PDF]
Genes EnvironFukushima R, Suzuki T, Kamiya H.
europepmc +1 more source
Neurologist's Black Swan: Molecular Basis of Prenatal Seizures. [PDF]
Int J Mol SciKustova AO +4 more
europepmc +1 more source
Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis.
Endocr RevChang M, Wang JC.
europepmc +1 more source