Results 121 to 130 of about 37,620 (216)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Gene ontology (GO) annotation.

, 2015
Gene ontology (GO) annotation.
Yuqian Wu (549440), Chun Liu (47227), Qingyou Xia (47221), Renwen Long (711291), Tingcai Cheng (47225), Bohua Fu (711290)   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Complete genome sequencing of Lactobacillus pentosus HP-B1718 and identification of the key enzyme for liquiritin biotransformation

Frontiers in Microbiology
IntroductionAs a free aglycone with higher bioavailability and pharmacological activity, liquiritigenin can be obtained from liquiritin (liquiritigenin-4’-O-β-D-glucoside) catalyzed by Aryl-phospho-beta-D-glucosidase (designated as ApgA).
Zhi-Wen Tan, Xiang-Rui Mao, Qian-Meng Qi, Xiao-Han Wang, Meng-Jie Liu, Hang Wu, Lan-Fang Li, Zhao-Sen Fan, Shao-Yang Hou   +8 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Metarel: an Ontology to support the inferencing of Semantic Web relations within Biomedical Ontologies

, 2009
While OWL, the Web Ontology Language, is often regarded as the preferred language for Knowledge Representation in the world of the Semantic Web, the potential of direct representation in RDF, the Resource Description Framework, is underestimated. Here we
Bernard De Baets, Erick Antezana, Vladimir Mironov, Ward Blondé, Martin Kuiper   +4 more
core  

Assembly evaluation using gene annotation.

, 2019
We validated the quality of our assemblies by measuring annotation completeness using AGAPE gene annotation [22]. AGAPE determines genes that are longer than 300 bases, and matches each gene to the NCBI database.
Jaebum Kim (254105), J. Michael Cherry (7314254), Hoyong Lee (23256), Daehwan Lee (7314248), Gregory I. Lang (7314251), Juyeon Kim (3768763), Daehong Kwon (6477698), Giltae Song (703564), Jongin Lee (6477701), Seokwoo Kang (4871857)   +9 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Automatic Prediction and Annotation: There Are Strong Biases for Multigenic Families

Frontiers in Genetics, 2021
Catherine Mathé, Christophe Dunand
doaj   +1 more source