Results 141 to 150 of about 7,510,778 (382)

MicroScope: an integrated platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis

Nucleic Acids Res., 2019
Large-scale genome sequencing and the increasingly massive use of high-throughput approaches produce a vast amount of new information that completely transforms our understanding of thousands of microbial species.
D. Vallenet, Alexandra Calteau, Mathieu Dubois, Paul Amours, Adelme Bazin, Mylène Beuvin, Laura Burlot, Xavier Bussell, S. Fouteau, Guillaume Gautreau, Aurélie Lajus, Jordan Langlois, Rémi Planel, D. Roche, Johan Rollin, Zoé Rouy, Valentin Sabatet, C. Médigue   +17 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

GENCODE reference annotation for the human and mouse genomes

Nucleic Acids Res., 2018
The accurate identification and description of the genes in the human and mouse genomes is a fundamental requirement for high quality analysis of data informing both genome biology and clinical genomics. Over the last 15 years, the GENCODE consortium has
A. Frankish, M. Diekhans, Anne-Maud Ferreira, Rory Johnson, Irwin Jungreis, J. Loveland, Jonathan M. Mudge, Cristina Sisu, James C. Wright, J. Armstrong, If H. A. Barnes, Andrew E. Berry, A. Bignell, S. C. Sala, Jacqueline Chrast, Fiona Cunningham, T. Domenico, S. Donaldson, Ian T. Fiddes, C. García-Girón, J. Gonzalez, Tiago Grego, Matthew Hardy, Thibaut Hourlier, T. Hunt, Osagie G. Izuogu, Julien Lagarde, Fergal J. Martin, Laura Martínez, Shamika Mohanan, Paul Muir, Fábio C. P. Navarro, Anne Parker, Baikang Pei, F. Pozo, Magali Ruffier, Bianca M. Schmitt, Eloise Stapleton, M. Suner, Irina Sycheva, Barbara Uszczynska-Ratajczak, Jinrui Xu, Andrew D. Yates, D. Zerbino, Yan Zhang, Bronwen L. Aken, Jyoti Choudhary, M. Gerstein, R. Guigó, T. Hubbard, Manolis Kellis, B. Paten, A. Reymond, M. Tress, Paul Flicek   +54 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Unsupervised Classification for Tiling Arrays: ChIP-chip and Transcriptome

, 2011
Tiling arrays make possible a large scale exploration of the genome thanks to probes which cover the whole genome with very high density until 2 000 000 probes.
Aubourg, Sébastien, Brunaud, Véronique, Bérard, Caroline, Martin-Magniette, Marie-Laure, Robin, Stéphane   +4 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Gene Ontology: enhancements for 2011 [PDF]

, 2012
The Gene Ontology (GO) (http://www.geneontology.org) is a community bioinformatics resource that represents gene product function through the use of structured, controlled vocabularies.
Chan, J., Kishore, R., Sternberg, P., Van Auken, K.   +3 more
core  

RNA-seq-Based Gene Annotation and Comparative Genomics of Four Fungal Grass Pathogens in the Genus Zymoseptoria Identify Novel Orphan Genes and Species-Specific Invasions of Transposable Elements

G3: Genes, Genomes, Genetics, 2015
The fungal pathogen Zymoseptoria tritici (synonym Mycosphaerella graminicola) is a prominent pathogen of wheat. The reference genome of the isolate IPO323 is one of the best-assembled eukaryotic genomes and encodes more than 10,000 predicted genes ...
Jonathan Grandaubert, Amitava Bhattacharyya, E. Stukenbrock   +2 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

GeneMachine: gene prediction and sequence annotation

Bioinformatics, 2001
Abstract Motivation: A number of free-standing programs have been developed in order to help researchers find potential coding regions and deduce gene structure for long stretches of what is essentially ‘anonymous DNA’. As these programs apply inherently different criteria to the question of what is and is not a coding region, multiple ...
I, Makalowska, J F, Ryan, A D, Baxevanis
openaire   +2 more sources